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Table of Contents
Vol. 79, No. 3, 2007
Issue release date: October 2007
Section title: Original Paper
Urol Int 2007;79:267–272
(DOI:10.1159/000107961)

Stabilization of Calcium Oxalate Suspension by Urinary Macromolecules, Probably an Efficient Protection from Stone Formation

Baumann J.M.a · Affolter B.a · Caprez U.a · Clivaz C.b · Glück Z.c · Weber R.b
aStone Research Center Viollier, Biel, bBerne University of Applied Sciences, Division of Chemistry, Burgdorf, and cDepartment of Nephrology, Hospital Center Biel, Biel, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 22, 2006
Accepted: November 21, 2006
Published online: October 17, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: Crystal aggregation (AGN) destabilizes crystal suspensions and during crystalluria probably favors crystal apposition to kidney calcifications and preexisting stones. We analyzed inhibition of AGN and stabilization of calcium oxalate suspensions by urinary macromolecules (UM), urine and solutions with urinary citrate concentration. Materials and Methods: Solutions of UM (UMS) were obtained by a hemofiltration procedure from urine of 6 healthy men. Calcium oxalate suspensions were prepared in all solutions and urine by adjusting Ca2+ to 1.5 mM and by an oxalate titration to 1.0 mM. Crystallization was monitored measuring optical density (OD). Stability of suspensions (SS) was defined as the time without sedimentation and zeta potential (ZP) of crystals was measured. AGN was visualized by scanning electron microscopy and quantified by maximal OD. Results: UMS inhibited AGN and increased ZP and SS. Most inhibitory activity of urine could be attributed to UM. 3.3-fold dilution of UM reduced SS only by 30%. Conclusions: During crystalluria, UM of healthy men are supposed to protect from stone formation by inhibiting AGN and stabilizing crystal suspensions. As a probably important aspect, this protection was found to be limited in time and may favorably be influenced by an increase of diuresis.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 22, 2006
Accepted: November 21, 2006
Published online: October 17, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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