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Vol. 28, No. 4, 2007
Issue release date: October 2007
Section title: Original Paper
Neuroepidemiology 2007;28:193–196
(DOI:10.1159/000108110)

Nonsteroidal Anti-Inflammatory Drugs and the Risk of Parkinson Disease

Bornebroek M. · de Lau L.M.L. · Haag M.D.M. · Koudstaal P.J. · Hofman A. · Stricker B.H.C. · Breteler M.M.B.
Departments of aEpidemiology and Biostatistics and bNeurology, Erasmus Medical Center, Rotterdam, cDepartment of Neurology, Leiden University Medical Center, Leiden, and dInspectorate for Health Care, The Hague, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/2/2006
Accepted: 6/18/2007
Published online: 9/11/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: Several lines of evidence suggest a role of inflammatory processes in Parkinson disease, although it is still unclear whether inflammation is a cause or rather a consequence of neurodegeneration. Methods: In a prospective population-based cohort study among 6,512 participants aged ≧55 years, with repeated in-person examination, we evaluated the association between cumulative use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of Parkinson disease. Complete information on filled prescriptions was available from automated pharmacy records. Data were analyzed by means of Cox proportional hazards regression analysis, adjusted for age, sex, smoking habits and coffee consumption. Results: After an average 9.4 years of follow-up, 88 new cases of Parkinson disease were detected. No association was found between use of NSAIDs and the risk of Parkinson disease (adjusted hazard ratio for any NSAID use, 1.50; 95% confidence interval, 0.95–2.37). Conclusion: Our findings do not support the hypothesis that NSAIDs might decrease the risk of Parkinson disease.


  

Author Contacts

M.M.B. Breteler, MD, PhD
Department of Epidemiology and Biostatistics, Erasmus Medical Center
PO Box 1738
NL–3000 DR Rotterdam (The Netherlands)
Tel. +31 10 408 7930, Fax +31 10 408 9382, E-Mail m.breteler@erasmusmc.nl

  

Article Information

Published online: September 11, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 13

  

Publication Details

Neuroepidemiology

Vol. 28, No. 4, Year 2007 (Cover Date: October 2007)

Journal Editor: Feigin, V.L. (Auckland)
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/2/2006
Accepted: 6/18/2007
Published online: 9/11/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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