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Table of Contents
Vol. 86, No. 3, 2007
Issue release date: November 2007
Section title: Paper
Neuroendocrinology 2007;86:210–214
(DOI:10.1159/000108341)

Histamine and the Regulation of Body Weight

Jørgensen E.A.a, b · Knigge U.a, c · Warberg J.a · Kjær A.a, b
aCluster for Molecular Imaging, University of Copenhagen, bDepartment of Clinical Physiology, Nuclear Medicine and PET, and cDepartment of Surgery C, Rigshospitalet, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 11, 2007
Issue release date: November 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the present article we review current evidence pointing at an important role of histamine in the regulation of appetite and metabolism. Studies using both knockout mouse models as well as pharmacological studies have revealed that histamine acts as an anorexigenic agent via stimulation of histamine H1 receptors. One effect of histamine in the regulation of appetite is to act as a mediator of the inhibitory effect of leptin on appetite. It seems that histamine may attenuate and delay the development of leptin resistance in high-fat-diet-induced obesity. Furthermore, histamine may also act to accelerate lipolysis. Based on the current evidence of the involvement of histamine in the regulation of body weight, the histaminergic system is an obvious target for the development of pharmacological agents to control obesity. At present, H3 receptor antagonists that stimulate the histaminergic system may be the most promising histaminergic drugs for antiobesity therapy.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 11, 2007
Issue release date: November 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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