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Table of Contents
Vol. 24, No. 5, 2007
Issue release date: October 2007
Section title: Original Paper
Cerebrovasc Dis 2007;24:405–411
(DOI:10.1159/000108429)

Iron Stores and HFE Genotypes Are Not Related to Increased Risk of Ischemic Stroke

A Prospective Nested Case-Referent Study

Ekblom K.a · Hultdin J.a · Stegmayr B.c · Johansson I.d · Van Guelpen B.b · Hallmans G.d · Weinehall L.e · Johansson L.f · Wiklund P.-G.c · Marklund S.L.a
aClinical Chemistry, and bPathology, Department of Medical Biosciences, cMedicine, dNutrition Research, and eEpidemiology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, fDepartment of Medicine, Skellefteå County Hospital, Skellefteå, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 22, 2006
Accepted: April 23, 2007
Published online: September 18, 2007
Issue release date: October 2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: High iron levels can increase the formation of noxious oxygen radicals, which are thought to contribute to cerebrovascular disease. The aim of this prospective study was to determine if iron status and HFE genotypes constitute risk factors for stroke. Methods: First-ever stroke cases (231 ischemic and 42 hemorrhagic) and matched double referents from the population-based Northern Sweden cohorts were studied in a nested case-referent setting. Results: For total iron binding capacity, an increased risk of ischemic stroke was seen in the highest quartile (OR 1.80; 95% CI 1.14–2.83; p for trend 0.012). The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22–0.87; p for trend 0.028), but not in women. There was an increased risk of hemorrhagic stroke in the second (OR 4.07; 95% CI 1.09–15.20) and third quartile (OR 4.22; 95% CI 1.08–16.42) of ferritin. Neither quartiles of plasma iron concentrations nor the HFE C282Y and H63D genotypes were associated with ischemic or hemorrhagic stroke. Conclusions: Iron stores were not positively related to increased risk of ischemic stroke. Furthermore, HFE genotypes did not influence the risk of ischemic or hemorrhagic stroke.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 22, 2006
Accepted: April 23, 2007
Published online: September 18, 2007
Issue release date: October 2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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