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Vol. 24, No. 5, 2007
Issue release date: October 2007
Section title: Original Paper
Cerebrovasc Dis 2007;24:405–411
(DOI:10.1159/000108429)

Iron Stores and HFE Genotypes Are Not Related to Increased Risk of Ischemic Stroke

A Prospective Nested Case-Referent Study

Ekblom K. · Hultdin J. · Stegmayr B. · Johansson I. · Van Guelpen B. · Hallmans G. · Weinehall L. · Johansson L. · Wiklund P.-G. · Marklund S.L.
aClinical Chemistry, and bPathology, Department of Medical Biosciences, cMedicine, dNutrition Research, and eEpidemiology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, fDepartment of Medicine, Skellefteå County Hospital, Skellefteå, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/22/2006
Accepted: 4/23/2007
Published online: 9/18/2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: High iron levels can increase the formation of noxious oxygen radicals, which are thought to contribute to cerebrovascular disease. The aim of this prospective study was to determine if iron status and HFE genotypes constitute risk factors for stroke. Methods: First-ever stroke cases (231 ischemic and 42 hemorrhagic) and matched double referents from the population-based Northern Sweden cohorts were studied in a nested case-referent setting. Results: For total iron binding capacity, an increased risk of ischemic stroke was seen in the highest quartile (OR 1.80; 95% CI 1.14–2.83; p for trend 0.012). The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22–0.87; p for trend 0.028), but not in women. There was an increased risk of hemorrhagic stroke in the second (OR 4.07; 95% CI 1.09–15.20) and third quartile (OR 4.22; 95% CI 1.08–16.42) of ferritin. Neither quartiles of plasma iron concentrations nor the HFE C282Y and H63D genotypes were associated with ischemic or hemorrhagic stroke. Conclusions: Iron stores were not positively related to increased risk of ischemic stroke. Furthermore, HFE genotypes did not influence the risk of ischemic or hemorrhagic stroke.


  

Author Contacts

Dr. Kim Ekblom
Department of Medical Biosciences, Clinical Chemistry
Umeå University
SE–901 85 Umeå (Sweden)
Tel. +46 90 785 2458, Fax +46 90 77 81 97, E-Mail kim.ekblom@medbio.umu.se

  

Article Information

Received: December 22, 2006
Accepted: April 24, 2007
Published online: September 18, 2007
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 5, Number of References : 24

  

Publication Details

Cerebrovascular Diseases

Vol. 24, No. 5, Year 2007 (Cover Date: October 2007)

Journal Editor: Hennerici, M.G. (Mannheim)
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/22/2006
Accepted: 4/23/2007
Published online: 9/18/2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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