C-Reactive Protein and Fibrinogen in Acute Stroke Patients with and without Sleep ApneaDziewas R. · Ritter M. · Krüger L. · Berger S. · Langer C. · Kraus J. · Dittrich R. · Schäbitz W.R. · Ringelstein E.B. · Young P.
aDepartment of Neurology, University Hospital of Münster, and bInstitute of Clinical Chemistry and Laboratory Medicine, Münster, Germany; cDepartment of Neurology, University Hospital Salzburg, Salzburg, Austria
Background and Purpose: Although sleep apnea (SA) is a risk factor for ischemic stroke and an important prognosticator in affected patients, the exact pathophysiological link between SA and stroke remains to be established. We investigated whether levels of C-reactive protein (CRP) and fibrinogen are increased in patients with acute stroke and SA compared with stroke patients without SA. Patients and Methods: 117 consecutive patients with ischemic stroke admitted to our stroke unit within 12 h after stroke onset were included in this study. On admission, CRP and fibrinogen levels were determined. All patients received cardiorespiratory polygraphy during the first 72 h of their hospital stay. In all patients, demographic data, National Institutes of Health Stroke Scale score and cerebrovascular risk factors were assessed. Results: SA defined by an apnea-hypopnea index (AHI) of ≧10/h was found in 64 (55%) patients. Elevated CRP and fibrinogen levels were seen twice as often in patients with SA than in patients without (CRP: 52 vs. 26%; fibrinogen: 72 vs. 37%). After multivariate logistic regression analysis, an AHI of ≧10/h was independently correlated with raised levels of both of these parameters. Conclusion: SA is independently associated with raised levels of CRP and fibrinogen in patients with acute ischemic stroke. We assume that both proteins are part of the pathophysiological pathway linking SA to stroke.
Rainer Dziewas, MD
Department of Neurology, University Hospital of Münster
DE–48129 Münster (Germany)
Tel. +49 251 834 7955, Fax +49 251 834 8181, E-Mail firstname.lastname@example.org
Received: January 15, 2007
Accepted: May 11, 2007
Published online: September 19, 2007
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 52
Vol. 24, No. 5, Year 2007 (Cover Date: October 2007)
Journal Editor: Hennerici, M.G. (Mannheim)
ISSN: 1015–9770 (print), 1421–9786 (Online)
For additional information: http://www.karger.com/CED