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Vol. 93, No. 2, 2008
Issue release date: February 2008
Section title: Original Paper
Neonatology 2008;93:138–144
(DOI:10.1159/000108764)

A Systematic Review and Meta-Analysis of a Brief Delay in Clamping the Umbilical Cord of Preterm Infants

Rabe H. · Reynolds G. · Diaz-Rossello J.
aDepartment of Neonatology, Brighton and Sussex University Hospitals, Brighton, UK; bDepartment of Women’s and Child Health, Canberra Hospital, Canberra, Australia; cLatin American Centre for Perinatology, Pan American Health Organisation/World Health Organisation, Montevideo, Uruguay

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2006
Accepted: 7/17/2007
Published online: 9/21/2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: The optimal timing of clamping the umbilical cord in preterm infants at birth is the subject of continuing debate. Objective: To investigate the effects of a brief delay in cord clamping on the outcome of babies born prematurely. Methods: A retrospective meta-analysis of randomised trials in preterm infants was conducted. Data were collected from published studies identified by a structured literature search in EMBASE, PubMed, CINAHL and the Cochrane Library. All infants born below 37 weeks gestation and enrolled into a randomised study of delayed cord clamping (30 s or more) versus immediate cord clamping (less than 20 s) after birth were included. Systematic search and analysis of the data were done according to the methodology of the Cochrane collaboration. Results: Ten studies describing a total of 454 preterm infants were identified which met the inclusion and assessment criteria. Major benefits of the intervention were higher circulating blood volume during the first 24 h of life, less need for blood transfusions (p = 0.004) and less incidence of intraventricular hemorrhage (p = 0.002). Conclusions: The procedure of a delayed cord clamping time of at least 30 s is safe to use and does not compromise the preterm infant in the initial post-partum adaptation phase.


  

Author Contacts

Dr. Heike Rabe
Department of Neonatology, Brighton and Sussex University Hospitals
Eastern Road, Brighton BN2 5BE (UK)
Tel. +44 1273 696 955 (ext. 4195), Fax +44 1273 664 795
E-Mail Heike.Rabe@bsuh.nhs.uk

  

Article Information

Received: December 28, 2006
Accepted after revision: July 17, 2007
Published online: September 21, 2007
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 2, Number of References : 25

  

Publication Details

Neonatology (Fetal and Neonatal Research)

Vol. 93, No. 2, Year 2008 (Cover Date: February 2008)

Journal Editor: Halliday, H.L. (Belfast)
ISSN: 1661–7800 (Print), eISSN: 1661–7819 (Online)

For additional information: http://www.karger.com/NEO


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2006
Accepted: 7/17/2007
Published online: 9/21/2007

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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