Primary Cerebral ALK-1-Positive Anaplastic Large Cell Lymphoma in a Child
Case Report and Literature ReviewKarikari I.O. · Thomas K.K. · Lagoo A. · Cummings T.J. · George T.M.
aPediatric Neurosurgery Service and bDepartment of Pathology, Duke University Medical Center, Durham, N.C., cChildren’s Hospital of Austin, Austin, Tex., USA
A 4-year-old African American male was referred to the Pediatric Neurosurgery Service for evaluation of new onset seizures and worsening mental status. An MRI of the brain revealed a pineal region mass with diffuse leptomeningeal enhancement and compression of the basilar cisterns. A biopsy of the brain revealed histologic and immunophenotypic findings characteristic of ALK-1+ anaplastic large cell lymphoma (ALCL). ALCL rarely occurs in the central nervous system and poses a significant diagnostic challenge often leading to a delay in the initiation of appropriate treatment. We describe a case of a rapidly deteriorating clinical course in a child with central nervous system ALCL and review the current literature on ALCL occurring in the central nervous system.
Timothy M. George, MD
Children’s Hospital of Austin
1601 Rio Grande, Austin, TX 78701 (USA)
Tel. +1 512 324 8982, E-Mail email@example.com
Received: January 23, 2006
Accepted after revision: October 10, 2006
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 1, Number of References : 29
Vol. 43, No. 6, Year 2007 (Cover Date: November 2007)
Journal Editor: Frim, D.M. (Chicago, Ill.)
ISSN: 1016–2291 (print), 1423–0305 (Online)
For additional information: http://www.karger.com/PNE