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Vol. 45, No. 1, 2008
Issue release date: December 2007
Section title: Research Paper
J Vasc Res 2008;45:19–32
(DOI:10.1159/000109074)

The Influence of Exogenous Tissue Factor on the Regulators of Proliferation and Apoptosis in Endothelial Cells

Pradier A. · Ettelaie C.
Biomedical Section, Department of Biological Sciences, University of Hull, Hull, UK

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 1/8/2007
Accepted: 6/1/2007
Published online: 9/26/2007
Issue release date: December 2007

Number of Print Pages: 14
Number of Figures: 7
Number of Tables: 4

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Background: The exposure of tissue factor (TF) at the site of injury or trauma is a rapid process that leads to the initiation of blood coagulation as well as homeostatic processes giving rise to vascular repair. Aims and Methods: By exposing human endothelial cells to combinations of exogenous TF and factor VIIa (FVIIa) in serum-free medium, the influence of TF concentrations on cellular proliferation and apoptosis was investigated. Results: Lower concentrations of TF resulted in increased cellular proliferation as well as upregulation of cyclin D1, downregulation of p21 and p27 and induction of tube formation in vitro. Conversely, incubation with higher concentrations of TF resulted in the activation of caspase-3, expression of p53 and Bax, translocation of p53 into the nucleus and induction of DNA fragmentation. Incubation of the cells with TF/FVIIa led to a lower proliferation rate with additional upregulation in p27. Conclusions: TF seems to have a bifunctional role in determining the fate of endothelial cells, depending on the concentration and the interactions of this protein. The release of TF in the locality of the injured tissue makes this protein an ideal factor for ascertaining the level of injury and determining the fate of the cells.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dr. Camille Ettelaie
Biomedical Section, Department of Biological Sciences
University of Hull, Cottingham Road
Hull, HU6 7RX (UK)
Tel. +44 1482 465 528, Fax +44 1482 465 458, E-Mail C.Ettelaie@hull.ac.uk

  

Article Information

Received: January 8, 2007
Accepted after revision: June 1, 2007
Published online: September 26, 2007
Number of Print Pages : 14
Number of Figures : 7, Number of Tables : 4, Number of References : 29

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 45, No. 1, Year 2008 (Cover Date: December 2007)

Journal Editor: Meininger, G.A. (Columbia, Mo.)
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 1/8/2007
Accepted: 6/1/2007
Published online: 9/26/2007
Issue release date: December 2007

Number of Print Pages: 14
Number of Figures: 7
Number of Tables: 4

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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