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Vol. 21, No. 1, 2008
Issue release date: January 2008
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2008;21:15–22
(DOI:10.1159/000109084)

Molecular Basis for the Regenerative Properties of a Secretion of the Mollusk Cryptomphalus aspersa

Brieva A.a · Philips N.c · Tejedor R.b · Guerrero A.a · Pivel J.P.a · Alonso-Lebrero J.L.a · Gonzalez S.d
aR&D Department, IFC SA, and bHospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain; cDepartment of Biological Sciences, School of Natural Sciences, Fairleigh Dickinson University, Teaneck, N.J., and dDermatology Service, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/9/2007
Accepted: 6/30/2007
Published online: 10/2/2007
Issue release date: January 2008

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/9/2007
Accepted: 6/30/2007
Published online: 10/2/2007
Issue release date: January 2008

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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