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Vol. 25, No. 5-6, 2007
Issue release date: January 2008
Section title: Original Paper
Blood Purif 2007;25:411–419
(DOI:10.1159/000109235)

Association between Vitamin D Receptor Gene Polymorphisms and Susceptibility to Chronic Kidney Disease and Periodontitis

Machado de Souza C. · Ribeiro Braosi A.P. · Luczyszyn S.M. · Rodrigues Ávila A. · Barbosa de Brito Jr. R. · Aparecido Ignácio S. · Probst C.M. · Riella M.C. · Santos Sotomaior V. · Távora Mira M. · Pecoits-Filho R. · Trevilatto P.C.
Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba,Paraná, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/23/2007
Accepted: 6/28/2007
Published online: 10/3/2007
Issue release date: January 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 4

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Background/Aims: Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of several genes involved in CKD and PD disease mechanisms. The aim of this work was to investigate the association between polymorphisms in the VDR gene and end-stage renal disease (ESRD) and PD. Methods: 222 subjects with and without ESRD (in hemodialysis) were divided into groups with and without PD. Polymorphisms TaqI and BsmI in the VDR gene were analyzed by PCR restriction fragment length polymorphism. The significance of differences in allele, genotype and haplotype frequencies between groups was assessed by the χ2 test (p value <0.05) and odds ratio (OR). Results: Allele G was associated with protection against ESRD: groups without versus with ESRD (GG) × (GA+AA): OR = 2.5, 95% CI = 1.4–4.6, p = 0.00; (G × A): OR = 1.5, 95% CI = 1.0–2.3, p = 0.02; (TG + CG) × (TA + CA): OR = 1.5, 95% CI = 1.0–2.3, p = 0.02. No association was observed between the study polymorphisms and susceptibility to or protection against PD. Conclusion: Allele G of the VDR BsmI polymorphism was associated with protection against ESRD.

© 2007 S. Karger AG, Basel


  

Author Contacts

Paula Cristina Trevilatto, DDS, PhD
Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná
Rua Imaculada Conceição, 1155
80215-901 Curitiba, PR (Brazil)
Tel. +55 41 3271 2618, Fax +55 41 3271 1657, E-Mail pctrev@yahoo.com.br

  

Article Information

Received: February 23, 2007
Accepted: June 28, 2007
Published online: October 3, 2007
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 4, Number of References : 71

  

Publication Details

Blood Purification

Vol. 25, No. 5-6, Year 2007 (Cover Date: January 2008)

Journal Editor: Leunissen, K.M.L. (Maastricht)
ISSN: 0253–5068 (Print), eISSN: 1421–9735 (Online)

For additional information: http://www.karger.com/BPU


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/23/2007
Accepted: 6/28/2007
Published online: 10/3/2007
Issue release date: January 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 4

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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