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Vol. 59, No. 1-2, 2008
Issue release date: December 2007
Section title: Original Paper
Eur Neurol 2008;59:31–37
(DOI:10.1159/000109258)

Positron Emission Tomography Facilitates Diagnosis of Early-Onset Alzheimer’s Disease

McMurtray A.M. · Licht E. · Yeo T. · Krisztal E. · Saul R.E. · Mendez M.F.
aDepartment of Neurology, University of California at Los Angeles (UCLA), and bVA Greater Los Angeles Healthcare System, Los Angeles, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/2006
Accepted: 4/4/2007
Published online: 10/4/2007

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: Clinical positron emission tomography (PET) may help in the evaluation of presenile patients with memory complaints for the presence of Alzheimer’s disease (AD). Methods: Clinical PET scans from 27 patients with clinically probable AD and early ages of onset (<65 years) were compared to PET scans from 27 age-matched controls presenting with memory complaints, but without dementia or mild cognitive impairment. Results: Compared to controls, the AD patients had significant frontal, temporal and parietal hypometabolism bilaterally, and AD diagnosis correlated with left temporal and right temporoparietal hypometabolism. The sensitivity of temporoparietal hypometabolism for AD was 92.6%, the specificity 85.2%. Conclusion: Clinical PET imaging helps distinguish early-onset AD from patients with memory complaints not meeting criteria for dementia or mild cognitive impairment.


  

Author Contacts

M.F. Mendez
Neurobehavior (116AF; Bldg 500, 3S), VA Greater Los Angeles Healthcare
11301 Wilshire Blvd
Los Angeles, CA 90073 (USA)
Tel. +1 310 478 3711, ext. 42696, Fax +1 310 268 4181, E-Mail mmendez@ucla.edu

  

Article Information

Received: December 15, 2006
Accepted: April 4, 2007
Published online: October 4, 2007
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 31

  

Publication Details

European Neurology

Vol. 59, No. 1-2, Year 2008 (Cover Date: December 2007)

Journal Editor: Bogousslavsky, J. (Montreux)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/2006
Accepted: 4/4/2007
Published online: 10/4/2007

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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