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Vol. 216, No. 1, 2008
Issue release date: November 2007
Section title: EDEN Papers
Dermatology 2008;216:46–55
(DOI:10.1159/000109358)

Poor Reporting of Quality of Life Outcomes in Dermatology Randomized Controlled Clinical Trials

Le Cleach L.a · Chassany O.b · Levy A.c · Wolkenstein P.e · Chosidow O.d
aService de Dermatologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, bDépartement de la Recherche Clinique (AP-HP), Hôpital Saint-Louis, cServices de Dermatologie, Hôpital Saint-Louis, Université Paris 7, Denis Diderot, dHôpital Tenon (AP-HP), Université Paris 6, Pierre et Marie Curie, Paris, eCHU Henri-Mondor (AP-HP), Université Paris 12, Créteil, France

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Article / Publication Details

First-Page Preview
Abstract of EDEN Papers

Received: 5/15/2007
Accepted: 5/25/2007
Published online: 11/28/2007
Issue release date: November 2007

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Because many dermatological diseases are chronic but not life-threatening, consideration of their impact on health-related quality of life (QOL) seems essential. Objective: To analyze the use of QOL as an evaluation endpoint in randomized clinical trials concerning skin diseases. Methods: Studies identified by computerized search of 3 bibliographical databases were selected, and their data on QOL as an evaluation endpoint were collected and analyzed. Results: Among the 67 studies retained, 87% did not adequately describe the questionnaires; 75% did not address handling of missing data; 95% did not calculate the number of subjects needed to obtain the desired statistical power; 95% did not disclose before-and-after results as means of overall scores and each dimension. Conclusion: Our analysis highlighted methodological weaknesses in the use of QOL questionnaire and poor reporting of QOL outcomes in randomized clinical trials.

© 2008 S. Karger AG, Basel


  

Author Contacts

Laurence Le Cleach
Service de Dermatologie, Centre Hospitalier Sud Francilien
59 boulevard Henri Dunant
FR–91100 Corbeil-Essonnes (France)
Tel. +33 1 6090 3039, Fax +33 1 6090 7668, E-Mail laurence.lecleach@free.fr

  

Article Information

Received: May 15, 2007
Accepted: May 25, 2007
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 2, Number of References : 76

  

Publication Details

Dermatology

Vol. 216, No. 1, Year 2008 (Cover Date: November 2007)

Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of EDEN Papers

Received: 5/15/2007
Accepted: 5/25/2007
Published online: 11/28/2007
Issue release date: November 2007

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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