Azo Pigments and a Basal Cell Carcinoma at the ThumbEngel E. · Ulrich H. · Vasold R. · König B. · Landthaler M. · Süttinger R. · Bäumler W.
aDepartment of Dermatology and bInstitute of Organic Chemistry, University of Regensburg, Regensburg, cBASF AG, Ludwigshafen, Germany
Basal cell carcinoma is the most common malignant neoplasm of the skin, whereas the localization at the nail unit is very rare. We report the case of a 58-year-old patient with a periungual basal cell carcinoma at the thumb. The specific feature of the reported case is the frequent exposure to fishing baits that the patient had stained with an unknown colorant. The use of chromatography, mass spectrometry and infrared spectroscopy revealed the colorant as the azo pigment Solvent Red 8. Solvent Red 8 is a widespread synthetic azo pigment that is applied to stain consumer products. Compounds such as Solvent Red 8 can be cleaved to carcinogenic amines under, for example, light exposure, in particular after incorporation into the human body. As a result of the frequent skin contact to this azo pigment, this hazard compound might have induced the basal cell carcinoma in our patient.
Wolfgang Bäumler, PhD, Ass. Prof.
Department of Dermatology, University of Regensburg
DE–93042 Regensburg (Germany)
Tel. +49 941 944 9607, Fax +49 941 944 9647
Received: April 9, 2007
Accepted: May 30, 2007
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 15
Vol. 216, No. 1, Year 2008 (Cover Date: November 2007)
Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)
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