Cover

Development of the Pancreas and Neonatal Diabetes

1st ESPE Advanced Seminar in Developmental Endocrinology, Paris, May 2007

Editor(s): Scharfmann R. (Paris) 
Shield J.P.H. (Bristol) 
Table of Contents
Vol. 12, No. , 2007
Section title: Paper
Shield JPH, Scharfmann R (eds): Development of the Pancreas and Neonatal Diabetes. Endocr Dev. Basel, Karger, 2007, vol 12, pp 113-123
(DOI:10.1159/000109638)

Imprinting in Human Disease with Special Reference to Transient Neonatal Diabetes and Beckwith-Wiedemann Syndrome

Temple I.
Wessex Clinical Genetics Academic Group, Division of Human Genetics, University of Southampton, Southampton , UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/4/2007
Cover Date: 2007

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8385-5 (Print)
eISBN: 978-3-8055-8386-2 (Online)

Abstract

There are at least 6 well-studied imprinting domains on human autosomes. Each domain is under the regulatory control of an ‘imprinting centre’ that harbours a differentially methylated region. A number of molecular mechanisms result in differential silencing of some genes within these domains and gene expression is tightly regulated in normal individuals. However, this makes them vulnerable to naturally occurring genetic and epigenetic aberrations. Nine recognisable developmental syndromes have been described due to abnormalities within these 6 domains: transient neonatal diabetes (TND; at 6q24); Beckwith- Wiedemann syndrome (BWS) and Silver-Russell syndrome (at 11p15.5; 2 imprinted domains); maternal and paternal uniparental disomy syndromes (at 14q32); Angelman and Prader-Willi syndromes (at 15q11-13), and pseudohypoparathyroidism type 1b (at 20q12-13). Furthermore, it is now recognised that involvement at multiple domains can occur simultaneously and result in what has been described as the hypomethylation syndrome. TND and BWS are discussed in more detail as examples of imprinting disorders.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/4/2007
Cover Date: 2007

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8385-5 (Print)
eISBN: 978-3-8055-8386-2 (Online)


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