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Table of Contents
Vol. 16, No. 1, 2008
Issue release date: December 2007
Section title: Paper
Neurosignals 2008;16:75–84

The Role of Autophagy in Age-Related Neurodegeneration

McCray B.A. · Taylor J.P.
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA
email Corresponding Author

J. Paul Taylor

Taylor Lab, 233 Stemmler Hall

3450 Hamilton Walk

Philadelphia, PA 19104 (USA)

Tel. +1 215 573 2270, Fax +1 215 573 1153, E-Mail jpt@mail.med.upenn.edu

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Most age-related neurodegenerative diseases are characterized by accumulation of aberrant protein aggregates in affected brain regions. In many cases, these proteinaceous deposits are composed of ubiquitin conjugates, suggesting a failure in the clearance of proteins targeted for degradation. The 2 principal routes of intracellular protein catabolism are the ubiquitin proteasome system and the autophagy-lysosome system (autophagy). Both of these degradation pathways have been implicated as playing important roles in the pathogenesis of neurodegenerative disease. Here we describe autophagy and review the evidence suggesting that impairment of autophagy contributes to the initiation or progression of age-related neurodegeneration. We also review recent evidence indicating that autophagy may be exploited to remove toxic protein species, suggesting novel strategies for therapeutic intervention for a class of diseases for which no effective treatments presently exist.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: December 05, 2007
Issue release date: December 2007

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

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