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Table of Contents
Vol. 30, No. 1-3, 2008
Issue release date: December 2007
Section title: Original Paper
Dev Neurosci 2008;30:187–199
(DOI:10.1159/000109862)

Doublecortin Supports the Development of Dendritic Arbors in Primary Hippocampal Neurons

Cohen D.a, b · Segal M.a · Reiner O.b
Departments of aNeurobiology and bMolecular Genetics, The Weizmann Institute, Rehovot, Israel

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 23, 2006
Accepted: February 02, 2007
Published online: December 13, 2007
Issue release date: December 2007

Number of Print Pages: 13
Number of Figures: 7
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Doublecortin (DCX) is a microtubule-associated protein necessary for neuronal migration. In spite of its ubiquitous distribution in dendrites, its possible role in dendrite development has not yet been documented. The present study examined the effects of different expression levels of DCX on the arborization of dendrites in cultured hippocampal neurons. Reduced expression of DCX following RNAi transfection resulted in reduced branch points, total length and complexity of the dendrites. Overexpression of DCX resulted in an increase in branch points and complexity of the dendrites. In contrast to control green fluorescent protein cells, DCX-overexpressing cells maintained highly branched and complex dendritic trees when subjected to reduced neuronal activity by blockade of immature GABAA receptors. These results suggest that DCX supports developing dendrites, in addition to its role in neuronal migration.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 23, 2006
Accepted: February 02, 2007
Published online: December 13, 2007
Issue release date: December 2007

Number of Print Pages: 13
Number of Figures: 7
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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