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Vol. 77, No. 1, 2008
Issue release date: December 2007
Section title: Clinical Note
Psychother Psychosom 2008;77:57–60
(DOI:10.1159/000110061)

Repetitive Transcranial Magnetic Stimulation in Bulimia Nervosa: Preliminary Results of a Single-Centre, Randomised, Double-Blind, Sham-Controlled Trial in Female Outpatients

Walpoth M. · Hoertnagl C. · Mangweth-Matzek B. · Kemmler G. · Hinterhölzl J. · Conca A. · Hausmann A.
aDepartment of General Psychiatry, bLaboratory for Magnetic Brain Stimulation, Department of General Psychiatry, and cDepartment of Psychosomatic Medicine, Innsbruck Medical University, Innsbruck, and dDepartment of General Psychiatry, Regional Hospital Rankweil, Rankweil, Austria

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Article / Publication Details

First-Page Preview
Abstract of Clinical Note

Published online: 12/14/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS

Abstract

Background: Bulimia nervosa (BN) is often associated with depressive symptoms and treatment with antidepressants has shown positive effects. A shared deficient serotonergic transmission was postulated for both syndromes. The left dorsolateral prefrontal cortex was argued to regulate eating behaviour and to be dysfunctional in eating disorders. Methods: Fourteen women meeting DSM-IV criteria for BN were included in a randomised placebo-controlled double-blind trial. In order to exclude patients highly responsive to placebo, all patients were first submitted to a one-week sham treatment. Randomisation was followed by 3 weeks of active treatment or sham stimulation. As the main outcome criterion we defined the change in binges and purges. Secondary outcome variables were the decrease of the Hamilton Depression Rating Scale (HDRS), the Beck Depression Inventory (BDI) and the Yale-Brown Obsessive Compulsive Scale (YBOCS) over time. Results: The average number of binges per day declined significantly between baseline and the end of treatment in the two groups. There was no significant difference between sham and active stimulation in terms of purge behaviour, BDI, HDRS and YBOCS over time. Conclusion: These preliminary results indicate that repetitive transcranial magnetic stimulation (rTMS) in the treatment of BN does not exert additional benefit over placebo. A larger number of patients might clarify a further role of rTMS in the treatment of BN.


  

Author Contacts

Michaela Walpoth, MD
Department of General Psychiatry
Laboratory for Magnetic Brain Stimulation, Innsbruck Medical University
Anichstrasse 35, AT–6020 Innsbruck (Austria)
Tel. +43 512 504 23636, Fax +43 512 504 23628, E-Mail Michaela.Walpoth@i-med.ac.at

  

Article Information

Published online: December 14, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 21

  

Publication Details

Psychotherapy and Psychosomatics

Vol. 77, No. 1, Year 2008 (Cover Date: December 2007)

Journal Editor: Fava, G.A. (Bologna)
ISSN: 0033–3190 (print), 1423–0348 (Online)

For additional information: http://www.karger.com/PPS


Article / Publication Details

First-Page Preview
Abstract of Clinical Note

Published online: 12/14/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS


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