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Table of Contents
Vol. 110, No. 2, 2008
Issue release date: April 2008
Section title: Original Research
Cardiology 2008;110:135–141
(DOI:10.1159/000110493)

Cardiopulmonary Exercise Testing in Mild Heart Failure: Impact of the Mode of Exercise on Established Prognostic Predictors

Maeder M.T.a, c · Wolber T.a · Ammann P.a · Myers J.d · Brunner-La Rocca H.P.c · Hack D.a · Riesen W.b · Rickli H.a
aDivision of Cardiology, Department of Internal Medicine, and bInstitute for Clinical Chemistry and Hematology, Kantonsspital St. Gallen, St. Gallen, and cDivision of Cardiology, University Hospital Basel, Basel, Switzerland; dCardiology Division, Palo Alto Veterans Affairs Medical Center, Stanford University, Palo Alto, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: April 20, 2007
Accepted: June 23, 2007
Published online: October 31, 2007
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: In patients with heart failure (HF), peak oxygen consumption (peak VO2), the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and heart rate recovery (HRR) are established prognostic predictors. However, treadmill exercise has been shown to elicit higher peak VO2 values than bicycle exercise. We sought to assess whether the VE/VCO2 slope and HRR in HF also depend on the exercise mode. Methods: Twenty-one patients with mild HF on chronic β-blocker therapy underwent treadmill and bicycle cardiopulmonary exercise testing for measurement of peak VO2 and the VE/VCO2 slope. In patients with sinus rhythm (n = 16), HRR at 1 (HRR-1) and 2 min (HRR-2) after exercise termination was assessed. Results: Peak VO2 was higher during treadmill as compared with bicycle testing (21.7 ± 4.6 vs. 19.6 ± 3.4 ml/kg/min; p = 0.006). HRR-1 tended to be slower (15 bpm, interquartile range 8–19, vs. 18 bpm, interquartile range 11–22; p = 0.16), and HRR-2 was significantly slower after treadmill exercise (26 bpm, interquartile range 20–39, vs. 31 bpm, interquartile range 22–41; p = 0.04). In contrast, VE/VCO2 slope values did not differ between the test modes (32.9 ± 5.5 vs. 32.3 ± 5.0; p = 0.56). Conclusions: In contrast to peak VO2 and HRR, the VE/VCO2 slope is not affected by the exercise mode in patients with mild HF.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: April 20, 2007
Accepted: June 23, 2007
Published online: October 31, 2007
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.