Background: Increased production of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. Predictors of Mortality: Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF-I concentrations and random GH levels <2.5 µg/l measured by polyclonal radioimmunoassay result in optimal outcome. Other factors adversely influencing mortality include hypertension and a long interval between onset of the disorder and diagnosis. Conclusions: Analysis of recent reports suggests that adoption of treatment guidelines with appropriate post-treatment target ranges for GH and IGF-I, together with the availability of newer methods to control GH oversecretion, has significantly improved patient outcomes.
© 2007 S. Karger AG, Basel
Ian Holdaway, MD
Greenlane Clinical Centre, Department of Endocrinology
PO Box 92189
Auckland 1142 (New Zealand)
Tel. +64 9 307 4949, Fax +64 9 307 4993, E-Mail firstname.lastname@example.org
Published online: December 10, 2007
Number of Print Pages : 7
Number of Figures : 8, Number of Tables : 2, Number of References : 29
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 68, No. Suppl. 5, Year 2007 (Cover Date: December 2007)
Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)
For additional information: http://www.karger.com/HRE
Article / Publication Details
Published online: 12/10/2007
Issue release date: December 2007
Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 2
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: http://www.karger.com/HRP
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