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Vol. 5, No. 2, 2008
Issue release date: January 2008
Section title: Original Paper
Neurodegenerative Dis 2008;5:60–64
(DOI:10.1159/000110789)

Sorl1 as an Alzheimer’s Disease Predisposition Gene?

Webster J.A.a · Myers A.J.b · Pearson J.V.a · Craig D.W.a · Hu-Lince D.a · Coon K.D.a · Zismann V.L.a · Beach T.c, d · Leung D.e · Bryden L.e · Halperin R.F.a · Marlowe L.e · Kaleem M.e · Huentelman M.J.a · Joshipura K.a · Walker D.c, d · Heward C.B.f · Ravid R.i · Rogers J.c, d · Papassotiropoulos A.a, j · Hardy J.b · Reiman E.M.a, d, g, h · Stephan D.A.a, d
aNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz.; bDepartment of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, Fla.; cSun Health Research Institute, Sun City, Ariz.; dArizona Alzheimer’s Consortium, Phoenix, Ariz.; eLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Md.; fKronos Science Laboratories, gBanner Alzheimer’s Institute, Phoenix, Ariz., and hDepartment of Psychiatry, University of Arizona, Tucson, Ariz., USA; iRoyal Dutch Academy of Sciences, Amsterdam, The Netherlands; jDivision of Psychiatry Research, University of Zurich, Zurich, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/8/2007
Accepted: 6/4/2007
Published online: 11/1/2007
Issue release date: January 2008

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) ε4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dietrich A. Stephan
Neurogenomics Division, TGen, The Translational Genomics Research Institute
445 N. Fifth Street
Phoenix, AZ 85004 (USA)
Tel. +1 602 343 8727, Fax +1 602 343 8448, E-Mail dstephan@tgen.org

  

Article Information

J.A.W. and A.J.M. contributed equally.

Received: March 8, 2007
Accepted after revision: June 4, 2007
Published online: November 1, 2007
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 9

  

Publication Details

Neurodegenerative Diseases

Vol. 5, No. 2, Year 2008 (Cover Date: January 2008)

Journal Editor: Nitsch, R.M. (Zürich)
ISSN: 1660–2854 (print), 1660–2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/8/2007
Accepted: 6/4/2007
Published online: 11/1/2007
Issue release date: January 2008

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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