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Table of Contents
Vol. 15, No. 3-5, 1993
Issue release date: 1993
Section title: Development and Energy Metabolism
Dev Neurosci 1993;15:174–180
(DOI:10.1159/000111333)

Development of Enzymes of Energy Metabolism in the Neonatal Mammalian Brain

Clark J.B. · Bates T.E. · Cullingford T. · Land J.M.
Miriam Marks Department of Neurochemistry, Institute of Neurology Universityof London, UK

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Article / Publication Details

First-Page Preview
Abstract of Development and Energy Metabolism

Published online: August 18, 1994
Issue release date: 1993

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

The metabolic capability for the complete oxidation of glucose, i.e. aerobic glycolysis, is highly developed in the brains of neurologically mature (precocial) species at birth, whereas this activity is severely limited in the brains of neurologically immature (non-precocial) species such as the rat and human. The latter utilize a mixture of glucose and ketone bodies for synthetic and energetic activities and the advent of neurological competence associated with the capability for complete dependence on and oxidation of glucose must await the development of key enzymes such as the pyruvate dehydrogenase complex (PDHC). A similar relationship appears to exist with respect to the development of neurological maturity of different brain regions in a single species, the rat. The development of the enzymes of energy metabolism of neonatal rat brain will be discussed with respect to the energy fuels available to the neonatal brain. In particular mechanisms by which the PDHC develops in neonatal brain will be evaluated. Evidence suggests that this is due to a specific increase in enzyme protein in contrast to a general increase in mitochondrial activity.

© 1993 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Development and Energy Metabolism

Published online: August 18, 1994
Issue release date: 1993

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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