Monocytic, Th1 and Th2 Cytokine Alterations in the Pathophysiology of SchizophreniaNa K.-S.a · Kim Y.-K.a, b
Departments of aPsychiatry and bDivision of Brain Korea 21 Biomedical Science, Korea University, Ansan, Seoul, Korea
A growing body of evidence suggests that changes in the serum levels and cellular production of various cytokines are associated with the immunological abnormalities of schizophrenia. Several studies have examined alterations in T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in schizophrenia. We explored monocytic, Th1 and Th2 cytokines in 43 schizophrenia patients and 50 normal controls. The mitogen-induced production of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-4, γ-interferon (IFN-γ) and IL-2 was measured with enzyme-linked immunosorbent assays before and after antipsychotic treatment. IL-6 and TNF-α production by schizophrenic patients was significantly higher than by normal controls, while IL-2, IL-4 and IFN-γ production was significantly lower in schizophrenic patients. After 6 weeks of antipsychotic treatment, IL-6 and TNF-α production was significantly decreased, while IL-4, IFN-γ and IL-2 productions were not significantly changed. Our results suggest that increased monocytic cytokines and decreased Th1 and Th2 cytokines may be associated with the immunopathogenesis of acute psychotic schizophrenia, and that antipsychotics may play an important role in immune response by decreasing elevated monocytic cytokines.
© 2007 S. Karger AG, Basel
This paper was done as part of the master’s thesis (in medicine) of K.-S.N.
Received: January 26, 2007
Accepted after revision: July 4, 2007
Published online: November 23, 2007
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 3, Number of References : 75
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Vol. 56, No. 2-3, Year 2007 (Cover Date: February 2008)
Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)
For additional information: http://www.karger.com/NPS