Introduction: Advanced stage/metastatic soft tissue sarcoma
(STS) has a poor prognosis especially after failure
of the established first-line treatment. In patients with relapsed
leiomyosarcoma, however, the combination of
gemcitabine (G) and docetaxel (D) recently has emerged
as a valuable salvage therapy. Patients and Methods: A
retrospective analysis of G (900 mg/m2, days 1+8) and D
(100 mg/m2, day 8) was performed in 34 patients with
STS, and response rate (RR), overall survival (OS), time
to progression (TTP), and toxicities were evaluated. Results:
Analysis of these 34 patients revealed a RR of 15%
with no complete remission (CR) and 5 partial remissions
(PR). Of note, 4/5 PR were achieved in patients with
leiomyosarcoma. In 13 patients (38%) disease stabilization
(SD) could be achieved resulting in a clinical benefit
rate (CBR), defined as CR+PR+SD, of 53%. Median OS
was 12.5 and TTP was 2.4 months for the whole group
and 2.8 months for patients with leiomyosarcoma. A progression-
free rate at 3 months of 38% and 45%, respectively,
was observed in these 2 groups. Major side effects
were 47% hematological and 26% grade 3/4 nonhematological
toxicity. Conclusion: With regard to the observed
CBR further use of GD seems to be warranted even in
pretreated patients with STS.
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