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Vol. 81, No. 2, 2008
Issue release date: January 2008
Section title: Original Paper
Pharmacology 2008;81:187–194
(DOI:10.1159/000111760)

Repeated Administration of Histamine Improves Memory Retrieval of Inhibitory Avoidance by Lithium in Mice

Zarrindast M.R.a-c · Parsaei L.d · Ahmadi S.e
aDepartment of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, bInstitute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, cInstitute for Cognitive Science Studies, dDepartment of Basic Sciences, Tehran North Unit, Azad University, Tehran, and eDepartment of Biological Science and Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/23/2007
Accepted: 8/24/2007
Published online: 11/28/2007
Issue release date: January 2008

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

The influence of repeated administration of histamine on lithium-induced state dependency has been investigated. A single-trial step-down inhibitory avoidance task was used to assess memory in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg), immediately after training (post-training), impaired inhibitory avoidance memory on the test day. Pre-test administration of lithium reversed amnesia induced by the drug given after training, with the maximum response at a dose of 10 mg/kg. Repeated intracerebroventricular (i.c.v.) administration of histamine (20 µg/mouse) for 3 consecutive days followed by 5 days of no drug treatment improved memory retrieval of inhibitory avoidance by a pre-test lower dose (5 mg/kg i.p.) of lithium. In contrast, 3 days of i.c.v. injections of both the histamine H1 receptor antagonist pyrilamine (40 µg/mouse) and the histamine H2 receptor antagonist ranitidine (6.25 and 12.5 µg/mouse) prevented the improving effect of pre-test lithium (10 mg/kg i.p.) on memory retrieval. The results suggest that the repeated administration of histaminergic agents may induce a sensitization which affects the memory impairment induced by lithium.

© 2008 S. Karger AG, Basel


  

Author Contacts

M.R. Zarrindast
Department of Pharmacology, School of Medicine
Tehran University of Medical Sciences
PO Box 13145-784, Tehran (Iran)
Tel./Fax +98 21 6640 2569, E-Mail zarinmr@ams.ac.ir

  

Article Information

This work was supported by a grant from Tehran University of Medical Sciences.

Received: April 23, 2007
Accepted: August 24, 2007
Published online: November 28, 2007
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 0, Number of References : 48

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 81, No. 2, Year 2008 (Cover Date: January 2008)

Journal Editor: Donnerer, J. (Graz)
ISSN: 0031–7012 (Print), eISSN: 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/23/2007
Accepted: 8/24/2007
Published online: 11/28/2007
Issue release date: January 2008

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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