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Vol. 13, No. 2, 2008
Issue release date: February 2008
Section title: Original Paper
Audiol Neurotol 2008;13:86–96
(DOI:10.1159/000111780)

Effects of Round Window Dexamethasone on Residual Hearing in a Guinea Pig Model of Cochlear Implantation

James D.P. · Eastwood H. · Richardson R.T. · O’Leary S.J.
aDepartment of Otolaryngology, University of Melbourne, Parkville, and bBionic Ear Institute, East Melbourne, Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/22/2006
Accepted: 7/27/2007
Published online: 11/29/2007
Issue release date: February 2008

Number of Print Pages: 11
Number of Figures: 7
Number of Tables: 4

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

To study electric acoustic stimulation, we have developed a model of guinea pig cochlear implantation via a cochleostomy. Thirty minutes prior to implantation, a hyaluronic acid/carboxymethylcellulose bead, loaded with either dexamethasone or normal saline, was placed upon the round window membrane. Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, and 1 and 4 weeks later. Selected cochlear histology was performed. Results: Dexamethasone could be detected in the cochlea for 24 h after cochlear implantation. Thresholds were elevated across frequencies in all animals immediately after surgery. These thresholds recovered completely at and below 2 kHz, and partially at higher frequencies by 1 week after implantation. At 32 kHz, but not the lower frequencies, the presence of dexamethasone had a significant protective effect upon hearing, which increased in magnitude over time. The protection was greatest in difficult implantations where an intractable resistance to electrode insertion was met. There was a persistent foreign body reaction at the site of implantation of saline-treated implanted ears but not in the dexamethasone-treated implanted ears. Conclusion: Short-term preoperative delivery of dexamethasone through the round window can protect residual hearing during cochlear implantation, especially during technically difficult surgery.


  

Author Contacts

Stephen J. O’Leary
University of Melbourne, Department of Otolaryngology
Parkville, 3002 (Australia)
Tel. +61 3 9929 8366, Fax +61 3 9663 1958, E-Mail soleary@bionicear.org

  

Article Information

Received: December 22, 2006
Accepted after revision: July 27, 2007
Published online: November 29, 2007
Number of Print Pages : 11
Number of Figures : 7, Number of Tables : 4, Number of References : 43

  

Publication Details

Audiology and Neurotology (Basic Science and Clinical Research in the Auditory and Vestibulary Systems and Diseases of the Ear)

Vol. 13, No. 2, Year 2008 (Cover Date: February 2008)

Journal Editor: Harris, J.P. (San Diego, Calif.)
ISSN: 1420–3030 (Print), eISSN: 1421–9700 (Online)

For additional information: http://www.karger.com/AUD


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/22/2006
Accepted: 7/27/2007
Published online: 11/29/2007
Issue release date: February 2008

Number of Print Pages: 11
Number of Figures: 7
Number of Tables: 4

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


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