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Vol. 75, No. 2, 2008
Issue release date: March 2008
Section title: Review
Respiration 2008;75:224–238
(DOI:10.1159/000111820)

Chronic Obstructive Pulmonary Disease: A Chronic Systemic Inflammatory Disease

van Eeden S.F. · Sin D.D.
James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St. Paul’s Hospital, Vancouver, B.C., Canada

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 7/5/2007
Accepted: 9/14/2007
Published online: 11/28/2007
Issue release date: March 2008

Number of Print Pages: 15
Number of Figures: 3
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation in both the airways causing airway obstruction and the lung tissues causing emphysema. The disease is induced by inhalation of noxious gasses and particulate matter resulting in a chronic persistent inflammatory response in the lung, and the extent of the inflammatory reaction correlates with the severity of the disease. This chronic inflammatory response in the lung is also associated with a significant systemic inflammatory response with downstream adverse clinical health effects. The systemic response in COPD is associated with mortality, specifically cardiovascular mortality. This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dr. Stephan van Eeden
The James Hogg iCapture Centre for Cardiovascular and Pulmonary Research University of British Columbia
St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 (Canada)
Tel. +1 604 806 8351, Fax +1 604 806 8346, E-Mail svaneeden@mrl.ubc.ca

  

Article Information

Received: July 5, 2007
Accepted after revision: September 14, 2007
Published online: November 28, 2007
Number of Print Pages : 15
Number of Figures : 3, Number of Tables : 1, Number of References : 141

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 75, No. 2, Year 2008 (Cover Date: March 2008)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (Print), eISSN: 1423–0356 (Online)

For additional information: http://www.karger.com/RES


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 7/5/2007
Accepted: 9/14/2007
Published online: 11/28/2007
Issue release date: March 2008

Number of Print Pages: 15
Number of Figures: 3
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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