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Vol. 28, No. 2, 2008
Issue release date: January 2008
Section title: Original Report: Laboratory Investigation
Am J Nephrol 2008;28:324–329
(DOI:10.1159/000111825)

A Comparative Evaluation of Various Methods for Microalbuminuria Screening

Sarafidis P.A. · Riehle J. · Bogojevic Z. · Basta E. · Chugh A. · Bakris G.L.
aHypertension/Clinical Research Center, Department of Preventive Medicine, Rush University Medical Center, and bHypertensive Diseases Unit, Section of Endocrinology, Diabetes and Metabolism, University of Chicago-Pritzker School of Medicine, Chicago, Ill., USA; cSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA University Hospital, Aristotle University of Thesaloniki, Thessaloniki, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: 9/4/2007
Accepted: 10/16/2007
Published online: 11/29/2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aims: Microalbuminuria is a marker of abnormal vascular response and a predictor of cardiovascular morbidity and mortality. We evaluated a new quantitative office-based method to assess urinary albumin excretion (UAE) and compared it to other established methods. Methods: Spot urine samples from 165 patients were analyzed at a single study site using the HemoCue system, Clinitek Microalbumin, and Chemstrip Micral test, as well as at a central laboratory, where UAE and creatinine levels were measured. The central laboratory UAE values were used as reference. We evaluated the validity of the HemoCue results and compared them to the respective data for the laboratory albumin-to-creatinine ratio (ACR). Additionally, we assessed, diagnostic sensitivity, specificity, and positive and negative predictive values of all four methods, as well as the reproducibility of the HemoCue measurements. Results: Linear regression analysis demonstrated a good correlation for the HemoCue system (y = 0.9978x – 1.0217, R2 = 0.904) and ACR (y = 0.0815x + 0.3373, R2 = 0.784). Sensitivity and specificity for microalbuminuria diagnosis were 92 and 98% for HemoCue, 73 and 96% for ACR, 100 and 81% for Clinitek Microalbumin, and 70 and 83% for Chemstrip Micral dipstick, respectively. The correlation coefficient of duplicate HemoCue measurements was r = 0.98 (p < 0.001). Conclusions: The HemoCue system for microalbuminuria detection was as accurate and precise as laboratory ACR estimations. Its diagnostic performance was much better than that of widely used dipstick methods.


  

Author Contacts

Pantelis A. Sarafidis, MD, MSc, PhD
Section of Nephrology and Hypertension, 1st Department of Medicine
AHEPA University Hospital, Aristotle University of Thessaloniki
St. Kiriakidi 1, GR–54636 Thessaloniki (Greece)
Tel./Fax +30 2310 994 616, E-Mail psarafidis11@yahoo.gr

  

Article Information

Received: September 4, 2007
Accepted: October 16, 2007
Published online: November 29, 2007
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 3, Number of References : 16

  

Publication Details

American Journal of Nephrology

Vol. 28, No. 2, Year 2008 (Cover Date: January 2008)

Journal Editor: Bakris, G. (Chicago, Ill.)
ISSN: 0250–8095 (print), 1421–9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: 9/4/2007
Accepted: 10/16/2007
Published online: 11/29/2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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