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Table of Contents
Vol. 110, No. 4, 2008
Issue release date: June 2008
Section title: Original Research
Cardiology 2008;110:217–225
(DOI:10.1159/000112403)

Prognostic Value of Natriuretic Peptides in Chagas’ Disease: A 3-Year Follow-Up Investigation

Moreira M.V.a · Heringer-Walther S.c · Wessel N.d · Moreira Ventura T.b · Wang Y.c · Schultheiss H.-P.c · Walther T.c
aDepartment of Internal Medicine, Felicio Rocho Hospital, Universidade Federal de Minas Gerais, and bJulia Kubitchek Hospital, Belo Horizonte, Brazil; cDepartment of Cardiology and Pneumonology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, and dUniversity of Potsdam, Potsdam, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: March 21, 2007
Accepted: June 05, 2007
Published online: December 12, 2007
Issue release date: June 2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Background: Chagas’ disease (CD) affects around 18 million people in Latin America. To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM). Methods: Blood samples were obtained from 111 CD patients, 62 patients with DCM due to other causes, and 43 gender- and age-matched healthy subjects. The CD and DCM patients were subdivided according to their NYHA classification. Natriuretic peptide concentrations were determined by immunoradiometric assays. Results: ANP and more pronounced BNP levels were increased in CD and DCM patients in relation to the NYHA class. Circulating BNP concentrations were higher in CD patients in NYHA classes I–II than in the corresponding DCM patients (p = 0.020). Importantly, ANP and BNP were already significantly elevated in CD patients without systolic ventricular dysfunction (p ≤ 0.001). In CD patients, both peptides were highly correlated with echocardiographic parameters (p < 10–14). Both ANP and BNP had comparable ability to predict death or the necessity for heart transplant (p < 0.0001). Conclusion: Natriuretic peptide levels can be used as a marker of asymptomatic CD without ventricular dysfunction and thus could be an ideal tool to identify these patients for early therapy.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: March 21, 2007
Accepted: June 05, 2007
Published online: December 12, 2007
Issue release date: June 2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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