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Vol. 1, No. 1, 1978
Issue release date: 1978
Dev Neurosci 1978;1:15–30
(DOI:10.1159/000112549)
Paper

Serotonin as a Differentiation Signal in Early Neurogenesis

Lauder J.M. · Krebs H.
Department of Biobehavioral Sciences, University of Connecticut, Storrs, Conn., and A. Ribicoff Research Center, Norwich Hospital, Norwich, Conn.

Abstract

The hypothesis that serotonin (5-HT) influences the onset of differentiation (cessation of division) of prospective 5-HT target neurons during embryogenesis was tested by administering the 5-HT depleting drug p-chlorophenylalanine (pCPA) to pregnant rats and dating the time of last cell division for fetal neurons using long survival 3H-thymidine autoradiography. PCPA specifically retarded the onset of neuronal differentiation in brain regions known to contain 5-HT terminals or to have a high 5-HT content in the adult (5-HT target cells). Conversely, the 'stress' of daily vehicle injections accelerated onset of differentiation in these regions, possibly due to stimulation of 5-HT synthesis by glucocorticoids. These data support the model of 5-HT as a humoral signal for the differentiation of cells later recognized by 5-HT neurons as appropriate targets for synaptogenesis.

 goto top of outline Author Contacts

Dr. Jean M. Lauder, A. Ribicoff Research Center, Norwich Hospital, Box 508, Norwich, CT 06360 (USA)


 goto top of outline Article Information

Published online: May 26, 2010
Number of Print Pages : 16


 goto top of outline Publication Details

Developmental Neuroscience

Vol. 1, No. 1, Year 1978 (Cover Date: 1978)

Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (Print), eISSN: 1421–9859 (Online)

For additional information: http://www.karger.com/DNE


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