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Table of Contents
Vol. 80, No. 2, 2008
Issue release date: March 2008
Section title: Original Paper
Urol Int 2008;80:157–161
(DOI:10.1159/000112606)

Treatment for Chronic Prostatitis/ Chronic Pelvic Pain Syndrome: Levofloxacin, Doxazosin and Their Combination

Jeong C.W.a · Lim D.J.b · Son H.b · Lee S.E.c · Jeong H.b
Departments of Urology,aSeoul National University Hospital, Seoul, bSeoul National University Boramae Hospital, Seoul, and cSeoul National University Bundang Hospital, Seongnam, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 29, 2006
Accepted: August 02, 2007
Published online: March 19, 2008
Issue release date: March 2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome. Patients and Methods: Men with a NIH diagnosis of category III chronic prostatitis/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29). Results: The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001). Conclusions: For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 29, 2006
Accepted: August 02, 2007
Published online: March 19, 2008
Issue release date: March 2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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