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Table of Contents
Vol. 72, No. 3-4, 2007
Issue release date: January 2008
Section title: Clinical Study
Oncology 2007;72:147–151
(DOI:10.1159/000112731)

Pegylated Liposomal Doxorubicin (Caelyx®) in Metastatic Breast Cancer: A Community-Based Observation Study

Salzberg M.a · Thürlimann B.b · Hasler U.c · Delmore G.c · von Rohr A.d · Thürlimann A.b · Ruhstaller T.b · Stopatschinskaja S.e · von Moos R.f
aPharma Brains, Basel, bKantonsspital, St. Gallen, cKantonsspital, Frauenfeld, dKlinik Hirslanden, Zürich, eEssex Chemie AG, Lucerne, and fKantonsspital Graubünden, Chur, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 04, 2007
Accepted: July 07, 2007
Published online: December 17, 2007
Issue release date: January 2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: Pegylated liposomal doxorubicin (PLD) has improved therapy options significantly, as it causes less myelosuppression, nausea, vomiting, and alopecia than conventional doxorubicin, while maintaining efficacy. The goal of this survey was to determine whether the use of PLD in a community-based patient group is comparable regarding chemotherapeutic doses and side effects to preselected study patients. Methods: 100 questionnaires were randomly sent to Swiss oncologists in private practices, general hospitals and university hospitals. Results: The patient cohort was heterogeneous with respect to prior treatments. PLD was an active agent in metastatic breast cancer and was well tolerated by the majority of patients. The most common non-hematological side effects were hand-foot syndrome (HFS) and mucositis while only patients receiving a dose of 50 mg/m2 (recommended dose) experienced grade 4 HFS. The reported mean dose of PLD was 38.5 mg/m2. Conclusions: This community-based observational study supports previous reports indicating that PLD at a median dose of ≤40 mg/m2 every 4 weeks is an active, well-tolerated agent in non-selected, pretreated patients with metastatic breast cancer.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 04, 2007
Accepted: July 07, 2007
Published online: December 17, 2007
Issue release date: January 2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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