Journal Mobile Options
Table of Contents
Vol. 4, No. 2, 1981
Issue release date: 1981
Section title: Paper
Dev Neurosci 1981;4:150–156
(DOI:10.1159/000112751)

Influence of Nerve Growth Factor on the Embryonic Mouse Trigeminal Ganglion in Culture

Davies A.M. · Lumsden A.G.S. · Slavkin H.C. · Burnstock G.
Department of Anatomy, University College; Department of Anatomy, Guy's Hospital Medical School, London; Laboratory for Developmental Biology, University of Southern California, Los Angeles, Calif., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 9.00
Account: USD 8.00

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/18/2007
Issue release date: 1981

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Developing trigeminal ganglia have been excised from mouse embryos of 9, 10, 11 and 12 days gestation and grown in tissue culture. A quantitative method was used to assess the effect of nerve growth factor (NGF) and an antiserum to NGF (anti-NGF) on fiber outgrowth from the explanted ganglia. Fiber outgrowth from 9-day ganglia (E9 ganglia) appeared to be unaffected by the presence of NGF. However, the ganglia became increasingly responsive to NGF from embryonic day 10 through 12. The increased responsiveness to NGF in vitro coincided with the establishment of fiber contacts with peripheral target tissues in vivo. Anti-NGF produced no significant reduction of fiber outgrowth from E9 ganglia, but from later ganglia significant reductions were observed.

© 1981 S. Karger AG, Basel


  

Author Contacts

A. G. S. Lumsden, Department of Anatomy, Guy's Hospital Medical School, London SE1 9RT (England)

  

Article Information

Published online: December 18, 2007
Number of Print Pages : 7

  

Publication Details

Developmental Neuroscience

Vol. 4, No. 2, Year 1981 (Cover Date: 1981)

Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (print), 1421–9859 (Online)

For additional information: http://www.karger.com/DNE


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/18/2007
Issue release date: 1981

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.