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Vol. 108, No. 1, 2008
Issue release date: February 2008
Section title: Original Paper
Nephron Exp Nephrol 2008;108:e19–e26
(DOI:10.1159/000112912)

Urinary Human L-FABP Is a Potential Biomarker to Predict COX-Inhibitor-Induced Renal Injury

Tanaka T.a · Noiri E.a, d · Yamamoto T.b · Sugaya T.c · Negishi K.a · Maeda R.d · Nakamura K.c · Portilla D.e · Goto M.b · Fujita T.a
aDepartments of Nephrology and Endocrinology and Hemodialysis and Apheresis, Tokyo University Hospital, Tokyo, bDepartment of Urology, Nagoya University Hospital, Nagoya, cCMIC Co. Ltd., Tokyo, and dCenter for NanoBio Integration, University of Tokyo, Tokyo, Japan; eDivision of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Veteran Healthcare System, Little Rock, Ark., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2007
Accepted: 10/24/2007
Published online: 1/8/2008
Issue release date: February 2008

Number of Print Pages: 1
Number of Figures: 7
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE

Abstract

Background/Aim: A strong demand exists for the development of sensitive biomarkers in the nephrology field. We propose urinary human L-type fatty acid binding protein (L-FABP) as an earlier biomarker to detect the outcome of chronic renal injury induced by cyclooxygenase (COX) inhibitors using human L-FABP transgenic mice. Methods: After consuming a low-sodium diet for 2 weeks, transgenic mice were administered meloxicam or celecoxib with the low-sodium diet. Mice were sacrificed 2 days and 4 weeks after starting COX inhibitors, and urine was collected 24 and 48 h and 1, 2, 3, and 4 weeks after starting COX inhibitors. Celecoxib-treated mice were divided into responders or nonresponders according to urinary L-FABP levels, and histology, urinary L-FABP and peritubular capillary blood flow were evaluated. Results: Meloxicam-treated mice showed a higher blood pressure than control mice. Urinary L-FABP was significantly increased in COX inhibitor-treated mice. Peritubular capillary blood flow in all meloxicam-treated mice and in some celecoxib-treated mice was significantly decreased. Although blood urea nitrogen was not increased, interstitial fibrosis and macrophage infiltration were revealed, especially in meloxicam-treated mice. Responders showed an increase of fibrotic areas and correlations between urinary L-FABP and peritubular capillary blood flow. Conclusion: Urinary L-FABP is capable of revealing chronic renal injury induced by COX inhibitors.

© 2008 S. Karger AG, Basel


  

Author Contacts

Eisei Noiri, MD, PhD
107 Lab., Departments of Nephrology and Endocrinology
University of Tokyo, 7-3-1 Hongo, Bunkyo
Tokyo 113-8655 (Japan)
Tel./Fax +81 3 5814 8696, E-Mail noiri-tky@umin.ac.jp

  

Article Information

Received: July 11, 2007
Accepted: October 24, 2007
Published online: January 8, 2008
Number of Print Pages : 8
Number of Figures : 7, Number of Tables : 1, Number of References : 16

  

Publication Details

Nephron Experimental Nephrology

Vol. 108, No. 1, Year 2008 (Cover Date: February 2008)

Journal Editor: Hughes, J. (Edinburgh)
ISSN: 1660–2129 (Print), eISSN: 1660–2129 (Online)

For additional information: http://www.karger.com/NEE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2007
Accepted: 10/24/2007
Published online: 1/8/2008
Issue release date: February 2008

Number of Print Pages: 1
Number of Figures: 7
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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