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Table of Contents
Vol. 45, No. 3, 2008
Issue release date: April 2008
Section title: Research Paper
J Vasc Res 2008;45:244–250
(DOI:10.1159/000112939)

Balance between Angiopoietin-1 and Angiopoietin-2 Is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density

Post S.a, b · Peeters W.a · Busser E.a · Lamers D.a · Sluijter J.P.G.a, b · Goumans M.-J.a · de Weger R.A.a · Moll F.L.a · Doevendans P.A.a · Pasterkamp G.a, b · Vink A.a
aUniversity Medical Center and bInteruniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: February 25, 2007
Accepted: October 14, 2007
Published online: January 10, 2008
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Introduction: Atherosclerotic plaque microvessels are associated with plaque hemorrhage and rupture. The mechanisms underlying plaque angiogenesis are largely unknown. Angiopoietin (Ang)-1 and -2 are ligands of the endothelial receptor Tie-2. Ang-1 induces formation of stable vessels, whereas Ang-2 destabilizes the interaction between endothelial cells and their support cells. We studied the expression patterns of Ang-1 and -2 in relation to plaque microvessels. Methods and Results: Carotid endarterectomy specimens were studied (n = 100). Microvessel density (MVD) was correlated with the presence of macrophages and with a (fibro)atheromatous plaque phenotype. A negative correlation was observed between Ang-1 expression and MVD. A positive correlation was observed between the ratio of Ang-2/Ang-1 and MVD. Ang-2 expression was correlated with matrix metalloproteinase-2 (MMP-2) activity. Immunohistochemical staining of Ang-1 was observed in smooth muscle cells, whereas Ang-2 was detected in endothelial cells, smooth muscle cells and macrophages. Conclusions: In plaques with high MVD, the local balance between Ang-1 and Ang-2 is in favor of Ang-2. Plaque Ang-2 levels are associated with MMP-2 activity. Ang-2-induced MMP-2 activity might play a role in the development of (unstable) plaque microvessels.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: February 25, 2007
Accepted: October 14, 2007
Published online: January 10, 2008
Issue release date: April 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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