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Clinical Study

Pegylated Liposomal Doxorubicin in Recurrent Malignant Glioma: Analysis of a Case Series

Glas M.a, b · Koch H.a · Hirschmann B.a · Jauch T.a · Steinbrecher A.a · Herrlinger U.b · Bogdahn U.a · Hau P.a

Author affiliations

aDepartment of Neurology, University of Regensburg, Regensburg, and bClinical Neurooncology Unit, Department of Neurology, University of Bonn, Bonn, Germany

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Oncology 2007;72:302–307

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: April 12, 2007
Accepted: July 30, 2007
Published online: January 14, 2008
Issue release date: February 2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Background: Recurrent malignant glioma has a dismal prognosis, and therapeutic options are scarce. After previous potentially encouraging reports on liposomal pegylated doxorubicin (PEG-DOX) in this setting, PEG-DOX was applied to patients with recurrent malignant glioma in an institutional series. Methods: In a retrospective analysis, 49 patients with recurrent high-grade glioma (WHO III, n = 18; WHO IV, n = 31) were treated with PEG-DOX (days 1 and 14/28, 20 mg/m2, n = 26) alone or in combination with temozolomide (days 1–5/28, 200 mg/m2, n = 23). The response rate, progression-free survival and overall survival were evaluated. Results: The rate of progression-free patients at 6 months after initiation of therapy was 27% (WHO III, 33%; WHO IV, 23%). The median overall survival (mOS) after initiation of PEG-DOX (monotherapy and combination therapy) was 8 months (WHO III, 16 months; WHO IV, 7 months). The mOS after initiation of PEG-DOX monotherapy was 8 months, and after initiation of combination therapy, 10 months. Both regimens were well tolerated, with the main side effect being hematologic toxicity (grade 1–2, 8%; grade 3–4, 18%). Conclusion: These data demonstrate the safety and moderate efficacy of PEG-DOX ± temozolomide therapy in recurrent malignant glioma. The potential of this nonalkylating chemotherapy should be further explored.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: April 12, 2007
Accepted: July 30, 2007
Published online: January 14, 2008
Issue release date: February 2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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