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Vol. 42, No. 2, 2008
Issue release date: April 2008
Section title: Original Paper
Caries Res 2008;42:88–97
(DOI:10.1159/000113161)

Enamel Subsurface Lesion Remineralisation with Casein Phosphopeptide Stabilised Solutions of Calcium, Phosphate and Fluoride

Cochrane N.J. · Saranathan S. · Cai F. · Cross K.J. · Reynolds E.C.
Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/15/2007
Accepted: 11/9/2007
Published online: 1/15/2008
Issue release date: April 2008

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

Casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) and amorphous calcium fluoride phosphate (CPP-ACFP) solutions have been shown to remineralise enamel subsurface lesions. The aim of this study was to determine the effect of ion composition of CPP-ACP and CPP-ACFP solutions on enamel subsurface lesion remineralisation in vitro. CPP-bound and free calcium, phosphate and fluoride ion concentrations in the solutions were determined after ultrafiltration. The ion activities of the free ion species present were calculated using an iterative computational program. The mineral deposited in the subsurface lesions was analysed using transverse microradiography and electron microprobe. CPP was found to stabilise high concentrations of calcium, phosphate and fluoride ions at all pH values (7.0–4.5). Remineralisation of the subsurface lesions was observed at all pH values tested with a maximum at pH 5.5. The CPP-ACFP solutions produced greater remineralisation than the CPP-ACP solutions at pH 5.5 and below. The mineral formed in the subsurface lesions was consistent with hydroxyapatite and fluorapatite for remineralisation with CPP-ACP and CPP-ACFP, respectively. The activity gradient of the neutral ion pair CaHPO40 into the lesion was significantly correlated with remineralisation and together with HF0 were identified as important species for diffusion.

© 2008 S. Karger AG, Basel


  

Author Contacts

Prof. E.C. Reynolds
School of Dental Science, University of Melbourne
720 Swanston Street
Parkville, Vic. 3010 (Australia)
Tel. +61 3 9341 1547, Fax +61 3 9341 1596, E-Mail e.reynolds@unimelb.edu.au

  

Article Information

Received: June 15, 2007
Accepted after revision: November 9, 2007
Published online: January 15, 2008
Number of Print Pages : 10
Number of Figures : 3, Number of Tables : 4, Number of References : 51

  

Publication Details

Caries Research

Vol. 42, No. 2, Year 2008 (Cover Date: April 2008)

Journal Editor: Shellis, R.P.(Bristol)
ISSN: 0008–6568 (Print), eISSN: 1421–976X (Online)

For additional information: http://www.karger.com/CRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/15/2007
Accepted: 11/9/2007
Published online: 1/15/2008
Issue release date: April 2008

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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