Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Cover

The Window of Opportunity: Pre-Pregnancy to 24 Months of Age

61st Nestlé Nutrition Workshop, Pediatric Program, Bali, April 2007

Editor(s): Barker D.J.P. (Southampton) 
Bergmann R.L. (Berlin) 
Ogra P.L. (Buffalo, N.Y.) 
Table of Contents
Vol. 61, No. , 2008
Section title: Paper
Barker, D.J.P. (Southampton) (eds): The Window of Opportunity: Pre-Pregnancy to 24 Months of Age. . Basel, Karger, 2008, vol 61, pp 183-195
(DOI:10.1159/000113493)

Induction of Antigen-Specific Immunity in Human Neonates and Infants

Wilson C. · Kollmann T.
aDepartments of Immunology and Pediatrics, University of Washington, Seattle, WA, USA, and b Division of Infectious and Immunological Diseases, BC Children’s and Women’s Hospital, University of British Columbia, Vancouver, BC, Canada

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Complete book

  • Immediate access to all parts of this book
  • Cover-to-cover formats may be available
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restriction for personal use
read more

Pricing depends on hard-cover price


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 11, 2008
Cover Date: 2008

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8387-9 (Print)
eISBN: 978-3-8055-8388-6 (Online)

Abstract

The first months of life represent a period of heightened susceptibility to infection, but the immunological differences involved are as yet incompletely understood. T cellindependent B cell (antibody) responses are markedly compromised in the first year of life. T cell-dependent antibody responses mature much earlier, but neonates and infants may require multiple immunizations to achieve or sustain titers comparable to those in older individuals. Neonates can mount effective antigen-specific T cell responses, but CD4 T cell responses are often slower to develop, less readily sustained, and in general more easily biased towards a Th2 type response. The last observation likely reflects in part the less efficient capacity of neonatal dendritic cells to establish a milieu that favors a Th1 CD4 T cell response, but this limitation can be overcome given appropriate stimuli, as occurs in neonates immunized with bacillus Calmette-Guérin. We currently lack a clear mechanistic understanding of the molecular basis for these immunological differences between adults and neonates. The goal of ongoing and future studies is to generate the mechanistic insights needed to enable the rational design of vaccines and adjuvants for use in neonates and young infants, and thereby reduce the morbidity and mortality of infections early in life.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 11, 2008
Cover Date: 2008

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8387-9 (Print)
eISBN: 978-3-8055-8388-6 (Online)


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.