Cover

The Window of Opportunity: Pre-Pregnancy to 24 Months of Age

61st Nestlé Nutrition Workshop, Pediatric Program, Bali, April 2007

Editor(s): Barker D.J.P. (Southampton) 
Bergmann R.L. (Berlin) 
Ogra P.L. (Buffalo, N.Y.) 
Table of Contents
Vol. 61, No. , 2008
Section title: Paper
Barker, D.J.P. (Southampton) (eds): The Window of Opportunity: Pre-Pregnancy to 24 Months of Age. . Basel, Karger, 2008, vol 61, pp 243-254
(DOI:10.1159/000113498)

Environmental Influences on the Development of the Immune System: Consequences for Disease Outcome

Björkstén B.
Department of Allergy Prevention and Pediatrics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/11/2008
Cover Date: 2008

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8387-9 (Print)
eISBN: 978-3-8055-8388-6 (Online)

Abstract

Early T cell responses to external antigens and autoantigens are subject to a variety of regulatory mechanisms. A unifying link between the increase in both Th1-dependent autoimmune disease and Th2-linked atopic allergy would be a disturbed immune regulation involving T regulatory cells. There is a strong global correlation between childhood wheezing and diabetes. It is increasingly recognized that microbial colonization of the gastrointestinal tract, linked with lifestyle and/or geographic factors, may be important determinants of the heterogeneity in disease prevalence throughout the world. These suggestions are supported by observations that germ-free mice do not develop tolerance in the absence of a gut flora. The potential effects of environmental stimuli on immune function is greatest in early life including fetal life when systems and responses are developing, and the maternal influences during fetal life could be particularly important for the development of immune regulation and tolerance induction. In recent years, focus has switched from searching for environmental risk factors towards an interest in factors that could induce and maintain immune regulation and tolerance to allergens and autoantigens. Currently evaluated strategies include the use of immunomodulatory factors, such as probiotics, prebiotics, and dietary nutrients, although data are still insufficient to make specific recommendations.


  

Article Information

Number of Print Pages : 12

  

Publication Details

Book Serie: Nestlé Nutrition Workshop Series: Pediatric Program, Vol. 61, Year 2008 ISSN: 1661-6677 (Print), eISSN: 1662-3878 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1661-6677

Book Title: The Window of Opportunity: Pre-Pregnancy to 24 Months of Age (61st Nestlé Nutrition Workshop, Pediatric Program, Bali, April 2007)

Editor(s): Barker, D.J.P. (Southampton)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1661-6677&volume=61


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/11/2008
Cover Date: 2008

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8387-9 (Print)
eISBN: 978-3-8055-8388-6 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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