Complete Response of CNS-involved Olfactory Neuroendocrine Tumor Using Multimodal TherapyAhuja G. · Cuellar S. · Choudhry I. · Setty S. · Yao M. · Villano J.L.
a Department of Medicine, bDepartment of Pharmacy, c Department of Pathology, dDepartment of Otolaryngology, The University of Illinois at Chicago, USA
Introduction: Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable. Case Report: We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery. Conclusion: To our knowledge, this combination treatment approach has not been reported in the literature.
J. Lee Villano, M.D., Ph.D., University of Illinois at Chicago, Dept. of Medicine, Section of Hematology/Oncology, 909 S. Wolcott Ave. Rm. 3133 M/C 734, Chicago IL 60612, USA, Tel. +1 312 996 6768, E-mail email@example.com
Published online: February 8, 2008
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 12
Onkologie (International Journal for Cancer Research and Treatment)
Vol. 31, No. 3, Year 2008 (Cover Date: March 2008)
Journal Editor: Schmoll, H.-J. (Halle)
ISSN: 0378–584X (Print), eISSN: 1423–0240 (Online)
For additional information: http://www.karger.com/ONK