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Vol. 31, No. 3, 2008
Issue release date: March 2008
Onkologie 2008;31:119–121
Clinical Case · Kasuistik

Complete Response of CNS-involved Olfactory Neuroendocrine Tumor Using Multimodal Therapy

Ahuja G.a · Cuellar S.b · Choudhry I.c · Setty S.c · Yao M.d · Villano J.L.a
a Department of Medicine, bDepartment of Pharmacy, c Department of Pathology, dDepartment of Otolaryngology, The University of Illinois at Chicago, USA


Introduction: Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable. Case Report: We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery. Conclusion: To our knowledge, this combination treatment approach has not been reported in the literature.

 goto top of outline Author Contacts

J. Lee Villano, M.D., Ph.D., University of Illinois at Chicago, Dept. of Medicine, Section of Hematology/Oncology, 909 S. Wolcott Ave. Rm. 3133 M/C 734, Chicago IL 60612, USA, Tel. +1 312 996 6768, E-mail

 goto top of outline Article Information

Published online: February 8, 2008
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 12

 goto top of outline Publication Details

Onkologie (International Journal for Cancer Research and Treatment)

Vol. 31, No. 3, Year 2008 (Cover Date: March 2008)

Journal Editor: Schmoll, H.-J. (Halle)
ISSN: 0378–584X (Print), eISSN: 1423–0240 (Online)

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