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Vol. 26, No. 2, 2008
Issue release date: March 2008
Section title: Original Paper
Blood Purif 2008;26:138–144
(DOI:10.1159/000113506)

Correlation of Metabolic Syndrome with Residual Renal Function, Solute Transport Rate and Peritoneal Solute Clearance in Chronic Peritoneal Dialysis Patients

Chen H.-Y.a, b · Kao T.-W.b · Huang J.-W.b · Chu T.-S.b · Wu K.-D.b
aDivision of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, and bDivision of Nephrology,Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/23/2007
Accepted: 9/12/2007
Published online: 1/22/2008
Issue release date: March 2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Background: Metabolic syndrome (MetS) and insulin resistance (IR) strongly promote macrovascular complications and endothelial dysfunction. They accelerate the progression of renal dysfunction in chronic kidney disease patients. However, their correlation with residual renal function (RRF) and peritoneal characteristics have never been investigated. Methods: The inter-relationships of IR (homeostatic model assessment, HOMAIR), serum adiponectin level, body mass index (BMI), highly sensitive C-reactive protein (hs-CRP), RRF, peritoneal solute clearance (Kt/Vurea) and solute transport rate of 104 chronic peritoneal dialysis (PD) patients were examined. Results: Patients with (n = 57) and without (n = 47) clinically diagnosed MetS had the same degree of RRF, peritoneal Kt/Vurea, and solute transport rate. Higher HOMAIR (p = 0.011), BMI (p = 0.01) and hs-CRP (p = 0.032), as well as lower adiponectin (p = 0.019), were associated with lower peritoneal Kt/Vurea. Serum adiponectin was negatively associated with solute transport rate (p = 0.02). In multiple regression analysis, higher HOMAIR (p = 0.005), BMI (p = 0.021) and hs-CRP (p < 0.001) correlated with lower peritoneal Kt/Vurea. Conclusions: MetS plays an important role in both macrovascular complications and endothelial dysfunction in chronic PD patients, which correlates with changes in peritoneal solute clearance and solute transport rate but not RRF.

© 2008 S. Karger AG, Basel


  

Author Contacts

Kwan-Dun Wu, Division of Nephrology, Department of Internal Medicine
National Taiwan University Hospital, College of Medicine
National Taiwan University, No. 7, Chung-Shan South Road
Taipei 100 (Taiwan)
Tel. +886 2 2312 3456, ext. 5014, Fax +886 2 2394 9269, E-Mail kdw@ntumc.org

  

Article Information

Received: May 23, 2007
Accepted: September 12, 2007
Published online: January 22, 2008
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 27

  

Publication Details

Blood Purification

Vol. 26, No. 2, Year 2008 (Cover Date: March 2008)

Journal Editor: Ronco, C. (Vicenza)
ISSN: 0253–5068 (Print), eISSN: 1421–9735 (Online)

For additional information: http://www.karger.com/BPU


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/23/2007
Accepted: 9/12/2007
Published online: 1/22/2008
Issue release date: March 2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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