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Vol. 15, No. 1, 2008
Issue release date: February 2008
Section title: Originalarbeit · Original Article
Forsch Komplementärmed 2008;15:9–20
(DOI:10.1159/000113648)

An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin

Saller R. · Brignoli R. · Melzer J. · Meier R.
aInstitute of Complementary Medicine, Department of Internal Medicine, University Hospital Zurich, Switzerland bClinical Pharmacology – Tradyser GmbH, Rueschlikon ZH, Switzerland cDepartment of Gastroenterology, University of Basel, Liestal, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Originalarbeit · Original Article

Published online: 7/17/2009

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Background: The potential benefit of silymarin (special extract from the fruits of Silybum marianum) in the treatment of liver diseases remains a controversial issue. Methods: For this systematic review electronic databases identified 65 papers for the search terms silymarin, silibinin, silicristin or milk thistle and clinical trial. Only 19 complied with the criteria ‘double-’ or ‘single-blind’. These publications were analysed from a clinical point of view and meta-analytic calculations were performed. Results: The clinical evidence of a therapeutic effect of silymarin in toxic liver diseases is scarce. There is no evidence of a favourable influence on the evolution of viral hepatitis, particularly hepatitis C. In alcoholic liver disease, comparing with placebo, aspartate aminotransferase was reduced in the silymarin-treated groups (p = 0.01) while alkaline phosphatase was not. In liver cirrhosis, mostly alcoholic, total mortality was 16.1% with silymarin vs. 20.5% with placebo (n.s.); liver-related mortality was 10.0% with silymarin vs. 17.3% with placebo (p = 0.01). Conclusions: Based on the available clinical evidence it can be concluded - concerning possible risks / probable benefits - that it is reasonable to employ silymarin as a supportive element in the therapy of Amanita phalloides poisoning but also (alcoholic and grade Child ‘A’) liver cirrhosis. A consistent research programme, consolidating existing evidence and exploring new potential uses, would be very welcome.


  

Publication Details

Forschende Komplementärmedizin / Research in Complementary Medicine ()
Official Organ of ‘Schweizerische Medizinische Gesellschaft für Phytotherapie’, Official Organ of ‘European Society for Complementary and Natural Medicine’,

Vol. 15, No. 1, Year 2008 (Cover Date: February 2008)

ISSN: 1661-4119 (Print), eISSN: 1661-4127 (Online)

For additional information: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&ProduktNr=235750&searchWhat=books


Article / Publication Details

First-Page Preview
Abstract of Originalarbeit · Original Article

Published online: 7/17/2009

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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