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Vol. 31, No. 3, 2008
Issue release date: March 2008
Section title: Original Article · Originalarbeit
Onkologie 2008;31:107–112
(DOI:10.1159/000113795)

Early Prediction of Therapy Outcome in Patients with High-Risk Soft Tissue Sarcoma Using Positron Emission Tomography

Kasper B.a · Dietrich S.a · Dimitrakopoulou-Strauss A.b · Strauss L.G.b · Haberkorn U.b · Ho A.D.a · Egerer G.a
a Department of Internal Medicine V, University of Heidelberg, bClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 2/8/2008
Issue release date: March 2008

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT

Abstract

Background: We used 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) to evaluate the FDG uptake in patients with soft tissue sarcoma (STS). Treatment effect was assessed with regard to prediction of therapy outcome. Patients and Methods: The ongoing evaluation includes 27 patients with high-risk STS receiving chemotherapy consisting of doxorubicin and ifosfamide (AI-G regimen), or etoposide, ifosfamide and doxorubicin (EIA regimen). Patients were examined using PET prior to onset of therapy, and after completion of the first cycle of AI-G and after 2 cycles of EIA chemotherapy, respectively. Restaging according to RECIST was performed after 6 cycles of AI-G or 4 cycles of EIA chemotherapy and served as reference. Results: Clinical outcome of 27 evaluable patients was as follows: 2 patients with no evidence of disease, 7 with partial remission, 14 with stable disease, and 4 patients with progressive disease. A significant difference of the progression-free survival for patients with a decrease in the standardised uptake value (SUV; responders) in comparison to patients with an increase or stable SUV (non-responders) could be demonstrated (p = 0.0187). Conclusion: On the basis of these data, prediction of chemo-sensitivity of the tumour and moreover of the therapy outcome might be possible.

© 2008 S. Karger AG, Basel


  

Author Contacts

Dr. Bernd Kasper, Universität Heidelberg Abteilung Innere Medizin V, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany Tel. +49 622156-8008, Fax -6824, E-mail mail@berndkasper.de

  

Article Information

Published online: February 8, 2008
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 1, Number of References : 26

  

Publication Details

Onkologie (International Journal for Cancer Research and Treatment)

Vol. 31, No. 3, Year 2008 (Cover Date: March 2008)

Journal Editor: Schmoll, H.-J. (Halle)
ISSN: 0378–584X (Print), eISSN: 1423–0240 (Online)

For additional information: http://www.karger.com/ONK


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 2/8/2008
Issue release date: March 2008

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT


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