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Table of Contents
Vol. 7, No. 1-2, 1972
Issue release date: 1972
Section title: Paper
Eur Neurol 1972;7:65–73
(DOI:10.1159/000114413)

Leukocyte Iso- and Autoantibodies in Multiple Sclerosis (MS) with Special Regard to Complement-Dependent Cold-Reacting Auto-Lymphocytotoxins (CoCoCy)

Kuwert E. · Bertrams J.
Department of Virology and Immunology, Institute of Medical Microbiology, Ruhr University, Essen

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 23, 2008
Issue release date: 1972

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Studies on leukocyte antibodies in multiple sclerosis (MS) yielded positive results in 34% of 462 MS patients who were in the chronic stage of the disease, when the sera were tested at 15 °C against homologous lymphocytes of 10 cell donors bearing different HL-A antigens. The corresponding value in healthy controls was 7%. When autologous cells were used for demonstration of complement-dependant cold-reacting cytotoxins (auto-CoCoCy) the percentage of positive reactions rose up to 75%. No correlation of iso-CoCoCy with the HL-A antigens could be demonstrated. CoCoCy-positive sera did not react either with homologous or autologous lymphocytes at 37 °C. CoCoCy activity in sera was destroyed by means of 2-mercaptoethanol. The biological significance of CoCoCy in MS remains unclear.

© 1972 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 23, 2008
Issue release date: 1972

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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