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Vol. 14, No. 5, 2007
Issue release date: February 2008
Section title: Original Paper
Neuroimmunomodulation 2007;14:272–280
(DOI:10.1159/000115041)

Lymphocyte Subsets and the Role of Th1/Th2 Balance in Stressed Chronic Pain Patients

Kaufmann I. · Eisner C. · Richter P. · Huge V. · Beyer A. · Chouker A. · Schelling G. · Thiel M.
Department of Anesthesiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/29/2007
Accepted: 11/14/2007
Published online: 2/1/2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of lymphocyte subsets under stress and pain conditions is limited. Methods: We performed a comparative study in 15 patients with CRPS type I, 22 patients with FM and 37 age- and sex-matched healthy controls and investigated the influence of pain and stress on lymphocyte number, subpopulations and the Th1/Th2 cytokine ratio in T lymphocytes. Results: Lymphocyte numbers did not differ between groups. Quantitative analyses of lymphocyte subpopulations showed a significant reduction of cytotoxic CD8+ lymphocytes in both CRPS (p < 0.01) and FM (p < 0.05) patients as compared with healthy controls. Additionally, CRPS patients were characterized by a lower percentage of IL-2-producing T cell subpopulations reflecting a diminished Th1 response in contrast to no changes in the Th2 cytokine profile. Conclusions: Future studies are warranted to answer whether such immunological changes play a pathogenetic role in CRPS and FM or merely reflect the consequences of a pain-induced neurohumoral stress response, and whether they contribute to immunosuppression in stressed chronic pain patients.


  

Author Contacts

Manfred Thiel, MD, PhD
Department of Anesthesiology, Klinikum Grosshadern
Ludwig Maximilians University
DE–81377 Munich (Germany)
Tel. +49 89 7095 6426, Fax +49 89 7095 8886, E-Mail mthiel@med.uni-muenchen.de

  

Article Information

Received: August 29, 2007
Accepted: November 14, 2007
Published online: February 1, 2008
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 3, Number of References : 60

  

Publication Details

Neuroimmunomodulation

Vol. 14, No. 5, Year 2007 (Cover Date: February 2008)

Journal Editor: Savino, W. (Rio de Janeiro)
ISSN: 1021–7401 (Print), eISSN: 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/29/2007
Accepted: 11/14/2007
Published online: 2/1/2008

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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