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Table of Contents
Vol. 19, No. 1, 1980
Issue release date: 1980
Section title: Original Paper
Eur Neurol 1980;19:67–72
(DOI:10.1159/000115130)

Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

Luoma P.V. · Myllylä V.V. · Sotaniemi E.A. · Lehtinen I.A. · Hokkanen E.J.
Clinical Research Unit, Departments of Medicine and Neurology, University of Oulu, and the Deaconess Institute of Oulu, Oulu

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 05, 1979
Accepted: May 31, 1979
Published online: January 29, 2008
Issue release date: 1980

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Plasma high-density lipoprotein (HDL) cholesterol in 97 epileptics on long-term anticonvulsant therapy was investigated. Therapy with phenytoin alone or in combination with carbamazepine or phenobarbital was associated with elevated plasma HDL cholesterol levels as compared with controls. HDL cholesterol in patients treated with carbamazepine did not diverge from control values. Patients treated with phenytoin and phenobarbital in combination showed higher HDL cholesterol levels than those treated with phenytoin alone. There was an inverse correlation between the HDL cholesterol and serum triglyceride levels. The results demonstrate that high plasma HDL cholesterol might be associated with therapy involving some anticonvulsants known to be potent enzyme inducers. This suggests that the elevation of HDL cholesterol during therapy is probably related to the drug-caused enzyme induction phenomenon.

© 1980 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 05, 1979
Accepted: May 31, 1979
Published online: January 29, 2008
Issue release date: 1980

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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