Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism
and polycystic ovarian syndrome to rare ones such as Cushing’s syndrome, central hypothyroidism and
hypothalamic disorders. The mechanisms for the development of obesity vary in according to the
endocrine condition. Hypothyroidism is associated with accumulation of hyaluronic acid within various
tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis. The pathophysiology
of obesity associated with polycystic ovarian syndrome remains complex as obesity itself
may simultaneously be the cause and the effect of the syndrome. Net excess of androgen appears to be
pivotal in the development of central obesity. In Cushing’s syndrome, an interaction with thyroid and
growth hormones plays an important role in addition to an increased adipocyte differentiation and adipogenesis.
This review also describes remaining rare cases: hypothalamic obesity due to central hypothyroidism
and combined hormone deficiencies.
Copyright / Drug Dosage
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