Journal Mobile Options
Table of Contents
Vol. 146, No. 3, 2008
Issue release date: June 2008
Section title: Opinion Article
Int Arch Allergy Immunol 2008;146:177–189
(DOI:10.1159/000115885)

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

de Weck A.L.a · Sanz M.L.a · Gamboa P.M.b · Aberer W.d · Bienvenu J.e · Blanca M.c · Demoly P.f · Ebo D.G.h · Mayorga L.c · Monneret G.e · Sainte-Laudy J.g
aUniversity of Navarra, Pamplona, bHopital Basurto, Bilbao, and cCarlos Haya Hospital, Malaga, Spain; dUniversity of Graz, Graz, Austria; Centres Hospitaliers Universitaires, eLyon, fMontpellier and gLimoges, France; hDepartment of Immunology, University of Antwerp, Antwerp, Belgium

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Opinion Article

Received: 6/25/2007
Accepted: 10/18/2007
Published online: 2/11/2008
Issue release date: June 2008

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 7

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

For the diagnosis of allergy, cellular basophil activation tests (BAT), e.g. histamine or sulfidoleukotriene release tests, have long been introduced, but the expression of basophil activation markers such as CD63 and CD203c detected by flow cytometry has attracted more recent attention. A recent opinion paper in this Journal has stressed not only the potential but also the possible pitfalls of flow-cytometric BAT. We have applied clinical validation of various BAT in various ways for several years, and our experience shows that these new technologies have more potentials and perspectives than pitfalls. A comprehensive review of clinically validated studies on allergy to aeroallergens, insect venoms, latex, food allergens and drugs, e.g. myorelaxants, β-lactams, pyrazolones and non-steroidal anti-inflammatory drugs, as well as chronic urticaria shows clearly that even with different protocols, reproducible and meaningful results can be obtained. Although the available technologies may still be optimized and better standardized, there are no serious reasons to deprive allergic patients of clinically indicated BAT, which can be performed reliably by any laboratory with allergy and flow-cytometric capacity and expertise.

© 2008 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Prof. Alain de Weck
Beaumont 18
CH–1700 Fribourg (Switzerland)
Tel. +41 26 424 6910, Fax +41 26 424 6911
E-Mail alain.dew@bluewin.ch

  

Article Information

Received: June 25, 2007
Accepted after revision: October 18, 2007
Published online: February 11, 2008
Number of Print Pages : 13
Number of Figures : 2, Number of Tables : 7, Number of References : 143

  

Publication Details

International Archives of Allergy and Immunology

Vol. 146, No. 3, Year 2008 (Cover Date: June 2008)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Opinion Article

Received: 6/25/2007
Accepted: 10/18/2007
Published online: 2/11/2008
Issue release date: June 2008

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 7

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.