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Vol. 146, No. 3, 2008
Issue release date: June 2008
Section title: Original Paper
Int Arch Allergy Immunol 2008;146:212–218
(DOI:10.1159/000115889)

A Single Oral Sensitization to Peanut without Adjuvant Leads to Anaphylaxis in Mice

Proust B.a · Astier C.a, b · Jacquenet S.b · Ogier V.b · Magueur E.a · Roitel O.a · Belcourt C.a · Morisset M.a · Moneret-Vautrin D.A.a · Bihain B.E.b · Kanny G.a
aEA 3999 ‘Allergic Diseases: Diagnosis and Therapeutics’, Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Central Hospital, Nancy, and bJE 2482 Lipidomix, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/10/2007
Accepted: 10/22/2007
Published online: 2/11/2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: A model of peanut food allergy has been developed in mice using a simple sensitization protocol leading to a quantitatively measurable allergic response. Methods: C3H/HeJ mice received a single intragastric administration of whole peanut (80 mg) without adjuvant. Two weeks later, intraperitoneal challenge with peanut extract led to a severe anaphylaxis. Results: Anaphylactic reaction was evidenced by vascular leakage, severe clinical symptoms, a drop in body temperature, a decrease in breathing rate and also by increased concentrations of serum mouse mast cell protease-1. Sensitization to peanut was demonstrated by positive skin tests (ear swelling test and intradermal skin testing) and increased peanut-specific IgE levels. Conclusions: Thus, we obtained a model of severe peanut hypersensitivity within 2 weeks following single oral exposure without adjuvant. This model may be useful for further basic and applied studies on peanut allergy.

© 2008 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Prof. Gisèle Kanny
Laboratoire de Médecine et Thérapeutique Moléculaire
EA 3999 ‘Maladies Allergiques: Diagnostic et Thérapeutique’
15 rue du Bois de la Champelle, FR–54500 Vandoeuvre-lès-Nancy (France)
Tel. +33 3 83 67 82 11, Fax +33 3 83 67 89 99, E-Mail g.kanny@chu-nancy.fr

  

Article Information

Received: May 10, 2007
Accepted after revision: October 22, 2007
Published online: February 11, 2008
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 0, Number of References : 28

  

Publication Details

International Archives of Allergy and Immunology

Vol. 146, No. 3, Year 2008 (Cover Date: June 2008)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/10/2007
Accepted: 10/22/2007
Published online: 2/11/2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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