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Vol. 31, No. 6, 1991
Issue release date: 1991
Eur Neurol 1991;31:352–355
Original Paper

Sleep Disorders, Pain, and Depression in Parkinson’s Disease

Starkstein S.E.a · Preziosi T.J.b · Robinson R.G.c
aDepartment of Psychiatry and Behavioral Science, University of Buenos Aires, and Department of Behavioral Neurology, Institute of Neurological Investigation ‘Dr. Raul Carrea’, Buenos Aires, Argentina; bDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Md., USA; cDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore Md., USA


A consecutive series of patients with Parkinson’s disease (PD) were examined for the presence of sleep disturbances, pain, and depression. We found that patients with PD and major depression had significantly more sleep disturbances and severe pain than non-depressed patients with PD. Moreover, depression scores accounted for most of the variance in a stepwise regression analysis of the effect of numerous clinical variables on either sleep disorders or pain severity. These findings suggest that depression is the most important factor associated with the common problems of sleep disorder and pain among patients with PD.

 goto top of outline Author Contacts

Sergio E. Starkstein, MD, Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City IA 52242 (USA)

 goto top of outline Article Information

Received: July 27, 1990
Received in revised form: November 16, 1990
Published online: February 08, 2008
Number of Print Pages : 4

 goto top of outline Publication Details

European Neurology

Vol. 31, No. 6, Year 1991 (Cover Date: 1991)

Journal Editor: Bogousslavsky, J. (Montreux)
ISSN: 0014–3022 (Print), eISSN: 1421–9913 (Online)

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