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Original Paper

Effects of Acyclovir on Sensory Axonal Neuropathy, Segmental Motor Paresis and Postherpetic Neuralgia in Herpes zoster Patients

Mondelli M.a,d · Romano C.b · Passero S.c · Della Porta P.a · Rossi A.a

Author affiliations

Institutes of aNeurological Sciences, bDermatology, and cNervous and Mental Diseases, University of Siena, and dEMG Service, USL 7, Siena, Italy

Related Articles for ""

Eur Neurol 1996;36:288–292

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 02, 1995
Accepted: February 09, 1996
Published online: February 13, 2008
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of treatment. Electrodiagnostic examination of the nerves and muscles corresponding to the dermatomeric lesions was performed, including sensory and motor nerve conduction studies, blink reflex and electromyography (EMG). The patients treated with ACV showed a significant reduction in the number of cases in which there was electrophysiological evidence of axonal damage in afferent fibres of nerves arising from roots corresponding to affected dermatomes. The treated group also showed a smaller incidence of segmental motor neuritis, clinically evident or only detectable by EMG as denervation. However, there was no significant difference between groups as far as the incidence of PHN was concerned. Oral treatment with ACV therefore reduces peripheral sensory axonopathy due to ganglion damage and prevents the possibility of spread to anterior roots and spinal motoneurones. In this way it reduces the incidence of segmental motor neuritis, but does not reduce the incidence of PHN.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 02, 1995
Accepted: February 09, 1996
Published online: February 13, 2008
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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